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De novo bone formation underneath the sinus membrane supported by a bone patch: a pilot experiment in rabbit sinus model

Authors
 So‐Ra Yoon  ;  Jae‐Kook Cha  ;  Hyun‐Chang Lim  ;  Jung‐Seok Lee  ;  Seong‐Ho Choi  ;  Ui‐Won Jung 
Citation
 CLINICAL ORAL IMPLANTS RESEARCH, Vol.28(10) : 1175-1181, 2017 
Journal Title
 CLINICAL ORAL IMPLANTS RESEARCH 
ISSN
 0905-7161 
Issue Date
2017
Keywords
animal study ; bone morphogenetic protein-2 ; bone regeneration ; collagen ; dental implant ; histology ; maxillary sinus ; micro-computed tomography
Abstract
AIMS: The objectives of this study were to evaluate bone regeneration beneath a newly devised bone substitute combined with collagen membrane (called a bone patch) lying over a concomitantly placed mini-implant following sinus floor elevation and verify its usefulness as a carrier system for recombinant human bone morphogenetic protein-2 (rhBMP-2) in rabbits. MATERIALS AND METHODS: The sinus floor elevation procedure was performed bilaterally in five rabbits. Either a plain bone patch (control group) or an rhBMP-2-loaded patch (experimental group) was randomly placed beneath the elevated sinus membrane (SM) of both sinuses, where the mini-implants were concomitantly placed. Micro-computed tomographic and histologic analyses were performed at 4 weeks post-surgery. RESULTS: In micro-computed tomography, the median values of the total augmented volume and the mineralized bone volume were significantly higher in the experimental group than in the control group (161 vs. 122 mm3 [P < 0.01] and 48 vs. 42 mm3 [P < 0.05], respectively). Histometric analysis revealed the same outcomes, with new bone areas of 6.41 and 2.97 mm2 in the experimental and control groups, respectively (P < 0.001), and bone-to-implant contact ratios of 22.6% and 5.2%, respectively (P < 0.001). CONCLUSION: The newly devised bone patch in this study can support the elevated SM and facilitate bone regeneration from the basal bone with a reduced amount of biomaterial. The addition of rhBMP-2 may shorten the healing time for multidirectional bone regeneration toward the implant.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/clr.12935
DOI
10.1111/clr.12935
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160977
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