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Sinus augmentation using a histone deacetylase inhibitor in a calcium sulfate carrier in rabbit: A pilot study

Authors
 Jae Kook Cha  ;  Hyun‐Chang Lim  ;  Jung‐Seok Lee  ;  Seong‐Ho Choi  ;  Kyung Mi Woo  ;  Ui‐Won Jung 
Citation
 Journal of Biomedical Materials Research Part B - Applied Biomaterials, Vol.105(7) : 1916-1923, 2017 
Journal Title
 Journal of Biomedical Materials Research Part B - Applied Biomaterials 
ISSN
 1552-4973 
Issue Date
2017
MeSH
Animals ; Calcium Sulfate*/chemistry ; Calcium Sulfate*/pharmacology ; Drug Carriers*/chemistry ; Drug Carriers*/pharmacology ; Histone Deacetylase Inhibitors*/chemistry ; Histone Deacetylase Inhibitors*/pharmacology ; Rabbits ; Sinus Floor Augmentation*
Keywords
animal study ; calcium sulfate ; histone deacetylase inhibitor ; maxillary sinus augmentation ; sodium butyrate
Abstract
Histone deacetylase inhibitors such as sodium butyrate (SB) have been suggested to be promising candidate small molecules for bone regeneration. In this study, the capacity of SB loaded onto calcium sulfate (CaS) to enhance bone formation was investigated in a rabbit sinus model. Following preparation of the sinus access window on a randomly selected side, SB loaded onto CaS (CaS/SB) was grafted in five rabbits, and CaS alone (control) was grafted in another five rabbits. The animals were euthanized after 4 weeks for radiographic, histometric, and immunohistochemical analyses. There was a statistically significant difference in the total augmented volume between the groups in the radiographic analysis (158.22 ± 39.31 mm3 and 107.09 ± 39.69 mm3 , respectively, p = 0.040). The CaS/SB group showed a larger portion of mature lamellar bone and a higher level of mineralization of bone trabeculae, characterized by more intense labeling with osteocalcin compared with the control group in the immunohistochemical analysis. The number of osteocalcin-positive cells within the central area of the augmented sinus was significantly higher in the CaS/SB group than in the control group (179 ± 26.0 mm2 and 123 ± 33.2 mm2 , respectively, p = 0.027). In conclusion, CaS/SB exhibited superior osteogenic potential, especially in the central portion of the augmented sinus as well as improvement of the volume maintenance for sinus augmentation.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160976
DOI
10.1002/jbm.b.33727
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실)
Yonsei Authors
이중석(Lee, Jung Seok) ; 정의원(Jung, Ui Won) ; 차재국(Cha, Jae Kook) ; 최성호(Choi, Seong Ho)
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Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.33727
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