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Peripapillary Choroidal Thickness Change of Polypoidal Choroidal Vasculopathy after Anti-vascular Endothelial Growth Factor

 Kyou Ho Lee  ;  Seo Hee Kim  ;  Ji Min Lee  ;  Eui Chun Kang  ;  Hyoung Jun Koh 
 Korean Journal of Ophthalmology, Vol.31(5) : 431-438, 2017 
Journal Title
Korean Journal of Ophthalmology
Issue Date
Aged ; Angiogenesis Inducing Agents/administration & dosage* ; Bevacizumab/administration & dosage ; Choroid/blood supply* ; Choroid/pathology ; Choroid Diseases/diagnosis* ; Choroid Diseases/drug therapy ; Female ; Fluorescein Angiography ; Follow-Up Studies ; Fundus Oculi ; Humans ; Intravitreal Injections ; Macula Lutea/pathology ; Male ; Middle Aged ; Optic Disk/pathology* ; Ranibizumab/administration & dosage ; Retrospective Studies ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factor A/antagonists & inhibitors* ; Visual Acuity
Anti-vascular endothelial growth factor ; Choroid ; Macular degeneration ; Polypoidal choroidal vasculopathy
PURPOSE: To investigate the peripapillary choroidal thickness (PCT) of polypoidal choroidal vasculopathy (PCV) and exudative age-related macular degeneration (AMD) and to evaluate their responses to anti-vascular endothelial growth factor (VEGF).

METHODS: Thirty eyes with PCV and 25 eyes with exudative AMD who were treatment naïve were included in this study. PCT and subfoveal choroidal thickness were evaluated both before and after intravitreal anti-VEGF.

RESULTS: The initial mean PCT of PCV (153.78 ± 56.23 μm) was thicker than that of exudative AMD (88.77 ± 23.11 μm, p < 0.001). Temporal, superior, nasal, and inferior PCTs of PCV were all thicker than those observedin exudative AMD (all p < 0.05). After anti-VEGF, the mean PCT of PCV was significantly reduced (134.17 ± 41.66 μm, p < 0.001), but the same was not true not in exudative AMD (86.87 ± 22.54 μm, p = 0.392). PCTshowed a similar tendency in all quadrants.

CONCLUSIONS: PCV exhibits a thick choroid in the peripapillary region. PCT decreases after anti-VEGF in PCV but not in exudative AMD. In exudative AMD, subfoveal choroidal thickness decreased, but that in the peripapillary region did not.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eui Chun(강의천)
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Kim, Seo Hee(김서희) ORCID logo https://orcid.org/0000-0003-0319-7139
Lee, Kyou Ho(이규호)
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