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Deep insight into neutrophil trafficking in various organs

Authors
 Young‐Min Hyun  ;  Chang‐Won Hong 
Citation
 Journal of Leukocyte Biology, Vol.102(3) : 617-629, 2017 
Journal Title
 Journal of Leukocyte Biology 
ISSN
 0741-5400 
Issue Date
2017
MeSH
Animals ; Cell Movement/immunology* ; Humans ; Neutrophil Infiltration* ; Neutrophils/immunology* ; Organ Specificity/immunology
Keywords
cell trafficking/adhesion ; chemotaxis ; neutrophil ; neutrophil trafficking
Abstract
Neutrophils are professional phagocytes that constitute the first line of defense in humans. The primary function of neutrophils is to eliminate invading pathogens through oxidative and nonoxidative mechanisms. Because neutrophils rapidly migrate into inflammatory foci via diapedesis and chemotaxis, neutrophil recruitment has long been considered a hallmark of inflammation. Recent advances in intravital microscopic technologies using animal model systems have enabled researchers to directly visualize neutrophil trafficking. Consequently, the specific mechanisms of neutrophil transmigration have been identified, and even the reverse migration of neutrophils can be verified visually. Moreover, the detailed phenomena of neutrophil infiltration into various organs, such as the liver, lymphoid organs, and CNS have been identified. This progress in the study of neutrophil migration from the blood vessels to organs results in a deeper understanding of these immune cells' motility and morphology, which are closely related to the spatiotemporal regulation of the overall immune response. In this review, we discuss our current understanding of neutrophil trafficking in various organs.
Full Text
https://jlb.onlinelibrary.wiley.com/doi/abs/10.1189/jlb.1RU1216-521R
DOI
10.1189/jlb.1RU1216-521R
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Hyun, Young-Min(현영민) ORCID logo https://orcid.org/0000-0002-0567-2039
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160816
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