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Risk Stratification of Thyroid Nodules With Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS) Cytology Using Ultrasonography Patterns Defined by the 2015 ATA Guidelines

Authors
 Ji Hye Lee  ;  Kyunghwa Han  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Jung Hyun Yoon  ;  Vivian Y. Park  ;  Jin Young Kwak 
Citation
 ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, Vol.126(9) : 625-633, 2017 
Journal Title
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
ISSN
 0003-4894 
Issue Date
2017
MeSH
Adenocarcinoma, Follicular/diagnostic imaging* ; Adenocarcinoma, Follicular/pathology ; Adenoma/diagnostic imaging* ; Adenoma/pathology ; Adult ; Biopsy, Fine-Needle ; Carcinoma/diagnostic imaging* ; Carcinoma/pathology ; Carcinoma, Neuroendocrine/diagnostic imaging* ; Carcinoma, Neuroendocrine/pathology ; Carcinoma, Papillary ; Female ; Humans ; Hyperplasia ; Male ; Middle Aged ; Practice Guidelines as Topic ; Retrospective Studies ; Risk Assessment ; Thyroid Neoplasms/diagnostic imaging* ; Thyroid Neoplasms/pathology ; Thyroid Nodule/diagnostic imaging* ; Thyroid Nodule/pathology ; Thyroiditis, Autoimmune/diagnostic imaging* ; Thyroiditis, Autoimmune/pathology ; Thyroiditis, Subacute/diagnostic imaging* ; Thyroiditis, Subacute/pathology ; Ultrasonography
Keywords
AUS/FLUS ; BSRTC ; Bethesda System for Reporting Thyroid Cytopathology ; atypia of undetermined significance or follicular lesion of undetermined significance ; thyroid gland ; thyroid nodule ; ultrasonography
Abstract
PURPOSE: The purpose of this study was to evaluate the predictive value of ultrasonography (US) patterns based on the 2015 American Thyroid Association (ATA) guidelines for malignancy in atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) nodules.

METHODS: From January 2014 to August 2015, 133 thyroid nodules that were initially diagnosed as AUS/FLUS on fine needle aspiration (FNA) were included in this study. Each nodule was assigned a category with US patterns defined by the ATA guidelines. Clinical characteristics and US patterns were compared between the benign and malignant nodules, and malignancy rates were calculated according to the ATA guidelines.

RESULTS: The malignancy rate in the very low suspicion group was 0.0% in AUS/FLUS nodules. When applying the ATA guidelines, significant differences existed for US patterns between the benign and malignant nodules in the AUS group ( P = .032) but not the FLUS group ( P = .168).

CONCLUSIONS: Ultrasonography patterns by the 2015 ATA guidelines can provide risk stratification for nodules with AUS cytology but not for ones with FLUS cytology. For nodules with AUS/FLUS cytology with the very low suspicion pattern of the ATA guidelines, follow-up US might be recommended instead of repeat FNA.
Full Text
http://journals.sagepub.com/doi/abs/10.1177/0003489417719472
DOI
10.1177/0003489417719472
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Park, Vivian Youngjean(박영진) ORCID logo https://orcid.org/0000-0002-5135-4058
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
Lee, Ji Hye(이지혜) ORCID logo https://orcid.org/0000-0002-1501-9105
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160778
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