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18F-AV-1451 binds to motor-related subcortical gray and white matter in corticobasal syndrome

 Hanna Cho  ;  Min Seok Baek  ;  Jae Yong Choi  ;  Seung Ha Lee  ;  Joong Seok Kim  ;  Young Hoon Ryu  ;  Myung Sik Lee  ;  Chul Hyoung Lyoo 
 Neurology, Vol.89(11) : 1170-1178, 2017 
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Aged ; Amyloid/metabolism ; Aniline Compounds ; Brain/diagnostic imaging* ; Brain/metabolism ; Brain Mapping ; Carbolines ; Female ; Gray Matter/diagnostic imaging ; Humans ; Male ; Middle Aged ; Motor Activity/physiology ; Parkinsonian Disorders/diagnostic imaging ; Parkinsonian Disorders/metabolism ; Positron-Emission Tomography ; Radiopharmaceuticals ; Severity of Illness Index ; Stilbenes ; White Matter/diagnostic imaging ; tau Proteins/metabolism
OBJECTIVE: To investigate tau distribution in patients with corticobasal syndrome (CBS) using 18F-AV-1451 PET. METHODS: Six consecutively recruited patients with CBS and 20 age-matched healthy controls underwent 2 PET scans with 18F-AV-1451 (for tau) and 18F-florbetaben (for β-amyloid). We compared standardized uptake value ratio maps of the 18F-AV-1451 PET images between the patients with CBS and controls. RESULTS: Compared to controls, patients with CBS exhibited asymmetrically increased 18F-AV-1451 binding in the putamen, globus pallidus, and thalamus contralateral to the clinically more affected side and in the ipsilateral globus pallidus and dentate nucleus. Voxel-based comparison additionally showed asymmetrically increased 18F-AV-1451 binding in the focal regions of the precentral gray and white matter and in the midbrain, predominantly in the contralateral side. 18F-AV-1451 binding in the precentral white matter correlated with motor severity. CONCLUSIONS: 18F-AV-1451 asymmetrically binds to motor-related subcortical gray and white matter structures in patients with CBS. This pattern corresponds to tau pathology distribution in postmortem studies, and motor deficit in patients with CBS may be associated with tau accumulation predominantly in the subcortical white matter underlying the motor cortex, leading to disruptions in motor-related networks.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
류철형(Lyoo, Chul Hyoung) ORCID logo https://orcid.org/0000-0003-2231-672X
백민석(Baek, Min Seok) ORCID logo https://orcid.org/0000-0001-5250-9480
유영훈(Ryu, Young Hoon) ORCID logo https://orcid.org/0000-0002-9000-5563
이명식(Lee, Myung Sik) ORCID logo https://orcid.org/0000-0002-8413-1854
이승하(Lee, Seung Ha)
조한나(Cho, Hanna) ORCID logo https://orcid.org/0000-0001-5936-1546
최재용(Choi, Jae Yong)
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