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18F-AV-1451 binds to motor-related subcortical gray and white matter in corticobasal syndrome

DC FieldValueLanguage
dc.contributor.author류철형-
dc.contributor.author백민석-
dc.contributor.author유영훈-
dc.contributor.author이명식-
dc.contributor.author이승하-
dc.contributor.author조한나-
dc.contributor.author최재용-
dc.date.accessioned2018-07-20T08:01:54Z-
dc.date.available2018-07-20T08:01:54Z-
dc.date.issued2017-
dc.identifier.issn0028-3878-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160773-
dc.description.abstractOBJECTIVE: To investigate tau distribution in patients with corticobasal syndrome (CBS) using 18F-AV-1451 PET. METHODS: Six consecutively recruited patients with CBS and 20 age-matched healthy controls underwent 2 PET scans with 18F-AV-1451 (for tau) and 18F-florbetaben (for β-amyloid). We compared standardized uptake value ratio maps of the 18F-AV-1451 PET images between the patients with CBS and controls. RESULTS: Compared to controls, patients with CBS exhibited asymmetrically increased 18F-AV-1451 binding in the putamen, globus pallidus, and thalamus contralateral to the clinically more affected side and in the ipsilateral globus pallidus and dentate nucleus. Voxel-based comparison additionally showed asymmetrically increased 18F-AV-1451 binding in the focal regions of the precentral gray and white matter and in the midbrain, predominantly in the contralateral side. 18F-AV-1451 binding in the precentral white matter correlated with motor severity. CONCLUSIONS: 18F-AV-1451 asymmetrically binds to motor-related subcortical gray and white matter structures in patients with CBS. This pattern corresponds to tau pathology distribution in postmortem studies, and motor deficit in patients with CBS may be associated with tau accumulation predominantly in the subcortical white matter underlying the motor cortex, leading to disruptions in motor-related networks.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfNeurology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAmyloid/metabolism-
dc.subject.MESHAniline Compounds-
dc.subject.MESHBrain/diagnostic imaging*-
dc.subject.MESHBrain/metabolism-
dc.subject.MESHBrain Mapping-
dc.subject.MESHCarbolines-
dc.subject.MESHFemale-
dc.subject.MESHGray Matter/diagnostic imaging-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMotor Activity/physiology-
dc.subject.MESHParkinsonian Disorders/diagnostic imaging-
dc.subject.MESHParkinsonian Disorders/metabolism-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHRadiopharmaceuticals-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHStilbenes-
dc.subject.MESHWhite Matter/diagnostic imaging-
dc.subject.MESHtau Proteins/metabolism-
dc.title18F-AV-1451 binds to motor-related subcortical gray and white matter in corticobasal syndrome-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorHanna Cho-
dc.contributor.googleauthorMin Seok Baek-
dc.contributor.googleauthorJae Yong Choi-
dc.contributor.googleauthorSeung Ha Lee-
dc.contributor.googleauthorJoong Seok Kim-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorMyung Sik Lee-
dc.contributor.googleauthorChul Hyoung Lyoo-
dc.identifier.doi10.1212/WNL.0000000000004364-
dc.contributor.localIdA01333-
dc.contributor.localIdA04947-
dc.contributor.localIdA02485-
dc.contributor.localIdA02753-
dc.contributor.localIdA04628-
dc.contributor.localIdA03920-
dc.contributor.localIdA04695-
dc.relation.journalcodeJ02340-
dc.identifier.eissn1526-632X-
dc.identifier.pmid28814462-
dc.identifier.urlhttp://n.neurology.org/content/89/11/1170-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.alternativeNameBaek, Min Seok-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.alternativeNameLee, Myung Sik-
dc.contributor.alternativeNameLee, Seung Ha-
dc.contributor.alternativeNameCho, Hanna-
dc.contributor.alternativeNameChoi, Jae Yong-
dc.contributor.affiliatedAuthorLyoo, Chul Hyoung-
dc.contributor.affiliatedAuthorBaek, Min Seok-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.contributor.affiliatedAuthorLee, Myung Sik-
dc.contributor.affiliatedAuthorLee, Seung Ha-
dc.contributor.affiliatedAuthorCho, Hanna-
dc.contributor.affiliatedAuthorChoi, Jae Yong-
dc.citation.volume89-
dc.citation.number11-
dc.citation.startPage1170-
dc.citation.endPage1178-
dc.identifier.bibliographicCitationNeurology, Vol.89(11) : 1170-1178, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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