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Role of atrial wall thickness in wave-dynamics of atrial fibrillation

Authors
 Jun-Seop Song  ;  Jin Wi  ;  Hye-Jeong Lee  ;  Minki Hwang  ;  Byounghyun Lim  ;  Tae-Hoon Kim  ;  Jae-Sun Uhm  ;  Boyoung Joung  ;  Moon-Hyoung Lee  ;  Jeong-Wook Seo  ;  Hui-Nam Pak 
Citation
 PLoS One, Vol.12(8) : e0182174, 2017 
Journal Title
 PLoS One 
Issue Date
2017
MeSH
Aged ; Atrial Fibrillation/physiopathology ; Cadaver ; Female ; Heart Atria/physiopathology ; Humans ; Male ; Middle Aged
Abstract
BACKGROUND/AIMS: Atrial anatomy and thickness may affect the electrical wave-dynamics of atrial fibrillation (AF). We explored the relationship between left atrial (LA) wall thickness (LAWT) or LA geometry and AF wave-dynamics. METHODS: We included 15 patients with persistent AF (age, 62.3 ± 11.9 years) who underwent AF catheter ablation. We measured the LAWT, LA endocardial curvature, and SD-curvature (surface bumpiness) from preprocedural computed tomography images. We compared those anatomical characteristics with electrophysiologic parameters such as dominant frequency (DF), Shannon entropy (ShEn), or complex fractionated atrial electrogram (CFAE)-cycle length (CL), calculated from intracardiac bipolar electrograms (300-500 points, 5 s), acquired during ablation procedures. RESULTS: 1. LAWT (excluding fat) varied widely among patients, locations, and types of AF. LAWT was inversely correlated with LA volume (r = -0.565, p = 0.028) and positively correlated with SD-curvature (r = 0.272, p < 0.001). 2. LAWT was positively correlated with ShEn (r = 0.233, p < 0.001) and negatively correlated with CFAE-CL (r = -0.107, p = 0.038). 3. In the multivariate linear regression analyses for AF wave-dynamics parameters, DF (β = -0.29 [95% CI -0.44--0.14], p < 0.001), ShEn (β = 0.19 [95% CI 0.12-0.25], p < 0.001), and CFAE-CL (β = 7.49 [95% CI 0.65-14.34], p = 0.032) were independently associated with LAWT. CONCLUSION: Regional LAWT is associated with LA structural features, and has significant correlations with the wave-dynamics parameters associated with electrical wavebreaks or rotors in patients with persistent AF.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160743
DOI
10.1371/journal.pone.0182174
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
Yonsei Authors
김태훈(Kim, Tae-Hoon) ; 박희남(Pak, Hui Nam) ; 엄재선(Uhm, Jae Sun) ; 위진(Wi, Jin) ; 이문형(Lee, Moon Hyoung) ; 이혜정(Lee, Hye Jeong) ; 임병현(Lim, Byounghyun) ; 정보영(Joung, Bo Young)
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