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Arterial Stiffness Is Associated With Cytomegalovirus-Specific Senescent CD8+ T Cells

 Hee Tae Yu  ;  Jong‐Chan Youn  ;  Jong Hoon Kim  ;  Yeon‐Jae Seong  ;  Su‐Hyung Park  ;  Hyeon Chang Kim  ;  Won‐Woo Lee  ;  Sungha Park  ;  Eui‐Cheol Shin 
 Journal of the American Heart Association, Vol.6(9) : e006535, 2017 
Journal Title
 Journal of the American Heart Association 
Issue Date
Adult ; Aged ; Aged, 80 and over ; CD57 Antigens/immunology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/virology* ; Cell Separation/methods ; Cells, Cultured ; Cytomegalovirus/immunology ; Cytomegalovirus/pathogenicity* ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/physiopathology ; Cytomegalovirus Infections/virology* ; Female ; Flow Cytometry ; Host-Pathogen Interactions ; Humans ; Immunosenescence* ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Phosphoproteins/immunology ; Pulse Wave Analysis ; Republic of Korea ; Vascular Stiffness* ; Viral Matrix Proteins/immunology ; Young Adult
T cells ; arterial stiffness ; cytomegalovirus ; immunosenescence ; pulse wave velocity
BACKGROUND: Arterial stiffness is a well-known predictor of future cardiovascular events. Search for the underlying mechanism of arterial stiffening is still under way. We investigated the relationship between arterial stiffness and cytomegalovirus infection in terms of T-cell senescence. METHODS AND RESULTS: Arterial stiffness was evaluated using pulse wave velocity measurements in 415 Koreans (age 59±12 years). We also investigated the frequency of CD57+ or CD28null senescent T cells in peripheral blood lymphocytes and analyzed which immune parameters were correlated with pulse wave velocity. Furthermore, cytomegalovirus-specific T cells were stimulated with overlapping peptides covering pp65 protein, and T-cell function was evaluated by intracellular cytokine staining of interferon-γ, tumor necrosis factor-α, and CD107a. In a multivariate analysis, it was found that the frequency of CD57+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity after adjusting for traditional cardiovascular risk factors such as age, sex, diabetes mellitus history, smoking history, body mass index, blood pressure, serum creatinine, high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein. Cytomegalovirus pp65-specific T cells were more frequently observed in the CD8+CD57+ population than in the CD8+CD57- population, and multivariate analysis revealed that the frequency of cytomegalovirus pp65-specific interferon-γ+, tumor necrosis factor-α+, or CD107a+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity as well. CONCLUSIONS: We demonstrate that arterial stiffness is associated with senescent CD57+ T cells and CMV pp65-specific T cells in the CD8+ T-cell subset. The precise role of cytomegalovirus-specific, senescent T cells in vascular aging needs to be further investigated.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김종훈(Kim, Jong Hoon) ORCID logo https://orcid.org/0000-0002-3385-8180
김현창(Kim, Hyeon Chang) ORCID logo https://orcid.org/0000-0001-7867-1240
박성하(Park, Sung Ha) ORCID logo https://orcid.org/0000-0001-5362-478X
유희태(Yu, Hee Tae) ORCID logo https://orcid.org/0000-0002-6835-4759
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