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Arterial Stiffness Is Associated With Cytomegalovirus-Specific Senescent CD8+ T Cells

DC Field Value Language
dc.contributor.author김종훈-
dc.contributor.author김현창-
dc.contributor.author박성하-
dc.contributor.author유희태-
dc.date.accessioned2018-07-20T07:57:53Z-
dc.date.available2018-07-20T07:57:53Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160712-
dc.description.abstractBACKGROUND: Arterial stiffness is a well-known predictor of future cardiovascular events. Search for the underlying mechanism of arterial stiffening is still under way. We investigated the relationship between arterial stiffness and cytomegalovirus infection in terms of T-cell senescence. METHODS AND RESULTS: Arterial stiffness was evaluated using pulse wave velocity measurements in 415 Koreans (age 59±12 years). We also investigated the frequency of CD57+ or CD28null senescent T cells in peripheral blood lymphocytes and analyzed which immune parameters were correlated with pulse wave velocity. Furthermore, cytomegalovirus-specific T cells were stimulated with overlapping peptides covering pp65 protein, and T-cell function was evaluated by intracellular cytokine staining of interferon-γ, tumor necrosis factor-α, and CD107a. In a multivariate analysis, it was found that the frequency of CD57+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity after adjusting for traditional cardiovascular risk factors such as age, sex, diabetes mellitus history, smoking history, body mass index, blood pressure, serum creatinine, high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein. Cytomegalovirus pp65-specific T cells were more frequently observed in the CD8+CD57+ population than in the CD8+CD57- population, and multivariate analysis revealed that the frequency of cytomegalovirus pp65-specific interferon-γ+, tumor necrosis factor-α+, or CD107a+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity as well. CONCLUSIONS: We demonstrate that arterial stiffness is associated with senescent CD57+ T cells and CMV pp65-specific T cells in the CD8+ T-cell subset. The precise role of cytomegalovirus-specific, senescent T cells in vascular aging needs to be further investigated.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfJOURNAL OF THE AMERICAN HEART ASSOCIATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCD57 Antigens/immunology-
dc.subject.MESHCD8-Positive T-Lymphocytes/immunology-
dc.subject.MESHCD8-Positive T-Lymphocytes/virology*-
dc.subject.MESHCell Separation/methods-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCytomegalovirus/immunology-
dc.subject.MESHCytomegalovirus/pathogenicity*-
dc.subject.MESHCytomegalovirus Infections/diagnosis-
dc.subject.MESHCytomegalovirus Infections/immunology-
dc.subject.MESHCytomegalovirus Infections/physiopathology-
dc.subject.MESHCytomegalovirus Infections/virology*-
dc.subject.MESHFemale-
dc.subject.MESHFlow Cytometry-
dc.subject.MESHHost-Pathogen Interactions-
dc.subject.MESHHumans-
dc.subject.MESHImmunosenescence*-
dc.subject.MESHLinear Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPhosphoproteins/immunology-
dc.subject.MESHPulse Wave Analysis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHVascular Stiffness*-
dc.subject.MESHViral Matrix Proteins/immunology-
dc.subject.MESHYoung Adult-
dc.titleArterial Stiffness Is Associated With Cytomegalovirus-Specific Senescent CD8+ T Cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Dermatology-
dc.contributor.googleauthorHee Tae Yu-
dc.contributor.googleauthorJong‐Chan Youn-
dc.contributor.googleauthorJong Hoon Kim-
dc.contributor.googleauthorYeon‐Jae Seong-
dc.contributor.googleauthorSu‐Hyung Park-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorWon‐Woo Lee-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorEui‐Cheol Shin-
dc.identifier.doi10.1161/JAHA.117.006535-
dc.contributor.localIdA05233-
dc.contributor.localIdA01142-
dc.contributor.localIdA01512-
dc.contributor.localIdA02535-
dc.relation.journalcodeJ01774-
dc.identifier.eissn2047-9980-
dc.identifier.pmid28847915-
dc.subject.keywordT cells-
dc.subject.keywordarterial stiffness-
dc.subject.keywordcytomegalovirus-
dc.subject.keywordimmunosenescence-
dc.subject.keywordpulse wave velocity-
dc.contributor.alternativeNameKim, Jong Hoon-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameYu, Hee Tae-
dc.contributor.affiliatedAuthorKim, Jong Hoon-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorYu, Hee Tae-
dc.citation.volume6-
dc.citation.number9-
dc.citation.startPagee006535-
dc.identifier.bibliographicCitationJOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol.6(9) : e006535, 2017-
dc.identifier.rimsid43775-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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