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Effect of home-based exercise intervention on fasting insulin and Adipocytokines in colorectal cancer survivors: a randomized controlled trial

 Mi Kyung Lee  ;  Ji Young kim  ;  Dong il Kim  ;  Dong Woo Kang  ;  Ji Hye Park  ;  Ki Yong Ahn  ;  Hyuk In Yang  ;  Dong Hoon Lee  ;  Yun Ho Roh  ;  Ji Won Lee  ;  Sang Hui Chu  ;  Jeffrey A. Meyerhardt  ;  Lee W. Jones  ;  Nam Kyu Kim  ;  Justin Y. Jeon 
 Metabolism: Clinical and Experimental, Vol.76 : 23-31, 2017 
Journal Title
 Metabolism: Clinical and Experimental 
Issue Date
Adipokines/blood ; Aged ; Colorectal Neoplasms/blood ; Exercise/physiology ; Exercise Therapy/methods ; Female ; Humans ; Insulin/blood ; Male ; Middle Aged ; Resistance Training ; Self Care ; Survivors ; Treatment Outcome
Adipocytokines ; Colorectal cancer survivors ; Home-based exercise program ; Insulin ; Physical function
BACKGROUND AND AIMS: Elevated circulating insulin is associated with increased risk of recurrence and cancer mortality in early-stage colorectal cancer (CRC). We conducted a randomized controlled trial to determine the effect of a 12-week home-based exercise program on fasting insulin, adipocytokines, and physical function in CRC survivors. METHODS: One hundred and twenty-three stage II-III CRC patients were randomly assigned to either a home-based exercise (n=62) or standard care control group (n=61) for 12weeks. Home-based exercise consisted of aerobic and resistance training, with a goal of obtaining ≥18 metabolic equivalent task (MET)-h/wk. Participants in the exercise group were instructed to participate in >18MET-h/wk. of aerobic and resistance exercise while the participants in the control group were asked to maintain their usual daily activity. The primary outcome was fasting insulin levels. Secondary outcomes were adiponectin, TNF-α levels and 6min walk distance from baseline to post-intervention. RESULTS: After the 12-weeks, moderate-vigorous physical activity participation increased from 9.1±14.7MET-h/wk. to 26.6±21.7MET-h/wk. in the exercise group, with no change in the control group (p<0.01 for group and time interaction). Circulating insulin level decreased by 1μU/ml (6.0±3.9 vs. 5.0±3.5, p=0.009) in the exercise group with no change in the control group (p=0.022 for group and time interaction). A similar trend was observed in TNF-α (p=0.030 for group and time interaction). Six minute walk distance increased by 25.2m in the exercise group with no change in the control group (p=0.061 for group and time interaction). CONCLUSIONS: The 12week home-based exercise program increased level of physical activity and decreased circulating insulin levels in CRC survivors.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
김남규(Kim, Nam Kyu) ORCID logo https://orcid.org/0000-0003-0639-5632
이지원(Lee, Ji Won) ORCID logo https://orcid.org/0000-0002-2666-4249
추상희(Chu, Sang Hui) ORCID logo https://orcid.org/0000-0001-6877-5599
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