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An indirect method for in vivo T2 mapping of [1-13 C] pyruvate using hyperpolarized 13 C CSI.

DC FieldValueLanguage
dc.contributor.author송호택-
dc.contributor.author최영숙-
dc.date.accessioned2018-07-20T07:53:52Z-
dc.date.available2018-07-20T07:53:52Z-
dc.date.issued2017-
dc.identifier.issn0952-3480-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160641-
dc.description.abstractAn indirect method for in vivo T2 mapping of 13 C-labeled metabolites using T2 and T2 * information of water protons obtained a priori is proposed. The T2 values of 13 C metabolites are inferred using the relationship to T2 ' of coexisting 1 H and the T2 * of 13 C metabolites, which is measured using routine hyperpolarized 13 C CSI data. The concept is verified with phantom studies. Simulations were performed to evaluate the extent of T2 estimation accuracy due to errors in the other measurements. Also, bias in the 13 C T2 * estimation from the 13 C CSI data was studied. In vivo experiments were performed from the brains of normal rats and a rat with C6 glioma. Simulation results indicate that the proposed method provides accurate and unbiased 13 C T2 values within typical experimental settings. The in vivo studies found that the estimated T2 of [1-13 C] pyruvate using the indirect method was longer in tumor than in normal tissues and gave values similar to previous reports. This method can estimate localized T2 relaxation times from multiple voxels using conventional hyperpolarized 13 C CSI and can potentially be used with time resolved fast CSI.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfNMR IN BIOMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlgorithms-
dc.subject.MESHAnimals-
dc.subject.MESHBiomarkers, Tumor/metabolism-
dc.subject.MESHBrain Neoplasms/metabolism-
dc.subject.MESHBrain Neoplasms/pathology-
dc.subject.MESHCarbon-13 Magnetic Resonance Spectroscopy/methods-
dc.subject.MESHFemale-
dc.subject.MESHGlioma/metabolism-
dc.subject.MESHGlioma/pathology-
dc.subject.MESHPyruvic Acid/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSignal Processing, Computer-Assisted-
dc.subject.MESHTissue Distribution-
dc.titleAn indirect method for in vivo T2 mapping of [1-13 C] pyruvate using hyperpolarized 13 C CSI.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorEunhae Joe-
dc.contributor.googleauthorHansol Lee-
dc.contributor.googleauthorJoonsung Lee-
dc.contributor.googleauthorSeungwook Yang-
dc.contributor.googleauthorYoung‐Suk Choi-
dc.contributor.googleauthorEunkyung Wang-
dc.contributor.googleauthorHo‐Taek Song-
dc.contributor.googleauthorDong‐Hyun Kim-
dc.identifier.doi10.1002/nbm.3690-
dc.contributor.localIdA02080-
dc.relation.journalcodeJ02376-
dc.identifier.eissn1099-1492-
dc.identifier.pmid28111820-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/nbm.3690-
dc.subject.keywordC6 glioma-
dc.subject.keywordT2 relaxation time-
dc.subject.keyword[1-13C] pyruvate-
dc.subject.keywordhyperpolarized 13C-
dc.subject.keywordin vivo metabolic CSI-
dc.contributor.alternativeNameSong, Ho Taek-
dc.contributor.affiliatedAuthorSong, Ho Taek-
dc.citation.volume30-
dc.citation.number5-
dc.citation.startPagee3690-
dc.identifier.bibliographicCitationNMR IN BIOMEDICINE, Vol.30(5) : e3690, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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