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Metabolic Complications among Korean Patients with HIV Infection: The Korea HIV/AIDS Cohort Study

 Dong Hyun Oh  ;  Jin Young Ahn  ;  Sang Il Kim  ;  Min Ja Kim  ;  Jun Hee Woo  ;  Woo Joo Kim  ;  Ji Hyeon Baek  ;  Shin-Woo Kim  ;  Bo Youl Choi  ;  Mi Hwa Lee  ;  Ju-yeon Choi  ;  Myung Guk Han  ;  Chun Kang  ;  June Myung Kim  ;  Jun Yong Choi  ;  Korea HIV/AIDS Cohort Study 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.32(8) : 1268-1274, 2017 
Journal Title
Issue Date
Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/diagnosis ; Adult ; Aged ; Aged, 80 and over ; Anti-Retroviral Agents/therapeutic use ; Blood Glucose/analysis ; Body Mass Index ; Cohort Studies ; Dyslipidemias/diagnosis ; Dyslipidemias/etiology ; HIV Infections/complications ; HIV Infections/diagnosis* ; HIV Infections/drug therapy ; Hospitals ; Humans ; Metabolic Syndrome/diagnosis* ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/etiology ; Middle Aged ; Prevalence ; Protease Inhibitors/therapeutic use ; Republic of Korea/epidemiology ; Risk Factors ; Young Adult
Dyslipidemia ; HIV Infection ; Metabolic Complication ; Protease Inhibitor
Currently, metabolic complications are the most common problem among human immunodeficiency virus (HIV)-infected patients, with a high incidence. However, there have been very few studies regarding metabolic abnormalities published in Asia, especially in Korea. This cross-sectional study was performed to investigate the prevalence of and risk factors for metabolic abnormalities in 1,096 HIV-infected patients of the Korea HIV/AIDS cohort study enrolled from 19 hospitals between 2006 and 2013. Data at entry to cohort were analyzed. As a result, the median age of the 1,096 enrolled subjects was 46 years, and most patients were men (92.8%). The metabolic profiles of the patients were as follows: median weight was 63.8 kg, median body mass index (BMI) was 22.2 kg/m², and 16.4% of the patients had a BMI over 25 kg/m². A total of 5.5% of the patients had abdominal obesity (waist/hip ratio ≥ 1 in men, ≥ 0.85 in women). Increased levels of fasting glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were present in 10.4%, 6.0%, 5.5%, and 32.1% of the patients. Decreased high-density lipoprotein (HDL) cholesterol levels were observed in 44.2% of the patients. High systolic blood pressure was present in 14.3% of the patients. In multivariate analysis, high BMI and the use of protease inhibitors (PIs) were risk factors for dyslipidemia in HIV-infected patients. In conclusion, proper diagnosis and management should be offered for the prevalent metabolic complications of Korean HIV-infected patients. Further studies on risk factors for metabolic complications are needed.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Oh, Dong Hyun(오동현)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
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