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Improving the efficacy of chlorhexidine-releasing elastomerics using a layer-by-layer coating technique

Authors
 Hyun-Sun JEON  ;  Eun-Ha JUNG  ;  Si-Mook KANG  ;  Eun-Song LEE  ;  Jeong-Woo LEE  ;  Baek-Il KIM 
Citation
 Dental Materials Journal, Vol.36(4) : 476-481, 2017 
Journal Title
 Dental Materials Journal 
ISSN
 0287-4547 
Issue Date
2017
MeSH
Anti-Infective Agents* ; Chlorhexidine* ; Humans ; Materials Testing ; Orthodontic Appliances*
Keywords
Chlorhexidine ; Drug delivery system ; Elastomeric ; Layer-by-layer technique
Abstract
The aims of this study were to identify the optimal concentration of coated orthodontic elastomerics using a layer-by-layer technique that can release chlorhexidine (CHX) as an antimicrobial material, and to measure the physical properties and antimicrobial effects of the coated elastomerics. Ethyl cellulose (EC) was used as the polymer, and five study groups with various combinations of solvents (i.e., ethanol and dichloromethane [DCM]) were included. The coated elastomerics were evaluated with a spectrophotometer to confirm the release of CHX, and their surfaces were observed by SEM. The CHX+EC+DCM group sustained antimicrobial release for the longest period (168 h, p<0.001) and exhibited the largest antimicrobial effect in an inhibition zone test using S. mutans for 7 days (p<0.05). This group had most effective physical properties and antimicrobial effects of coated elastomerics produced using a layerby-layer technique, and so its composition should be considered for use in clinical applications in orthodontics.
Files in This Item:
T201702735.pdf Download
DOI
10.4012/dmj.2016-337
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실)
Yonsei Authors
강시묵(Kang, Si-Mook) ORCID logo https://orcid.org/0000-0003-2341-3636
김백일(Kim, Baek Il) ORCID logo https://orcid.org/0000-0001-8234-2327
이은송(Lee, Eun Song) ORCID logo https://orcid.org/0000-0002-2949-4783
정은하(Jung, Eun Ha)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160607
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