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Improving the efficacy of chlorhexidine-releasing elastomerics using a layer-by-layer coating technique

DC FieldValueLanguage
dc.contributor.author김백일-
dc.contributor.author이은송-
dc.contributor.author정은하-
dc.contributor.author강시묵-
dc.date.accessioned2018-07-20T07:51:50Z-
dc.date.available2018-07-20T07:51:50Z-
dc.date.issued2017-
dc.identifier.issn0287-4547-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160607-
dc.description.abstractThe aims of this study were to identify the optimal concentration of coated orthodontic elastomerics using a layer-by-layer technique that can release chlorhexidine (CHX) as an antimicrobial material, and to measure the physical properties and antimicrobial effects of the coated elastomerics. Ethyl cellulose (EC) was used as the polymer, and five study groups with various combinations of solvents (i.e., ethanol and dichloromethane [DCM]) were included. The coated elastomerics were evaluated with a spectrophotometer to confirm the release of CHX, and their surfaces were observed by SEM. The CHX+EC+DCM group sustained antimicrobial release for the longest period (168 h, p<0.001) and exhibited the largest antimicrobial effect in an inhibition zone test using S. mutans for 7 days (p<0.05). This group had most effective physical properties and antimicrobial effects of coated elastomerics produced using a layerby-layer technique, and so its composition should be considered for use in clinical applications in orthodontics.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Japanese-
dc.publisherJapanese Society for Dental Materials and Devices-
dc.relation.isPartOfDENTAL MATERIALS JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnti-Infective Agents*-
dc.subject.MESHChlorhexidine*-
dc.subject.MESHHumans-
dc.subject.MESHMaterials Testing-
dc.subject.MESHOrthodontic Appliances*-
dc.titleImproving the efficacy of chlorhexidine-releasing elastomerics using a layer-by-layer coating technique-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Preventive Dentistry-
dc.contributor.googleauthorHyun-Sun JEON-
dc.contributor.googleauthorEun-Ha JUNG-
dc.contributor.googleauthorSi-Mook KANG-
dc.contributor.googleauthorEun-Song LEE-
dc.contributor.googleauthorJeong-Woo LEE-
dc.contributor.googleauthorBaek-Il KIM-
dc.identifier.doi10.4012/dmj.2016-337-
dc.contributor.localIdA00485-
dc.contributor.localIdA04635-
dc.contributor.localIdA03691-
dc.contributor.localIdA00049-
dc.relation.journalcodeJ00700-
dc.identifier.eissn1881-1361-
dc.identifier.pmid28420834-
dc.subject.keywordChlorhexidine-
dc.subject.keywordDrug delivery system-
dc.subject.keywordElastomeric-
dc.subject.keywordLayer-by-layer technique-
dc.contributor.alternativeNameKim, Baek Il-
dc.contributor.alternativeNameLee, Eun Song-
dc.contributor.alternativeNameJung, Eun Ha-
dc.contributor.affiliatedAuthorKim, Baek Il-
dc.contributor.affiliatedAuthorLee, Eun Song-
dc.contributor.affiliatedAuthorJung, Eun Ha-
dc.citation.volume36-
dc.citation.number4-
dc.citation.startPage476-
dc.citation.endPage481-
dc.identifier.bibliographicCitationDENTAL MATERIALS JOURNAL, Vol.36(4) : 476-481, 2017-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers

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