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Serum ferritin level is positively associated with insulin resistance and metabolic syndrome in postmenopausal women: A nationwide population-based study.

 Mi-Ra Cho  ;  Jin-Kyung Park  ;  Won-Jun Choi  ;  A-Ra Cho  ;  Yong-Jae Lee 
 MATURITAS, Vol.103(9) : 3-7, 2017 
Journal Title
Issue Date
Ferritin ; Inflammation ; Insulin resistance ; Menopause ; Metabolic syndrome
OBJECTIVE: Serum ferritin, a marker of iron metabolism, has recently emerged as a biomarker of chronic low-grade inflammation. After menopause, there is a remarkable increase in insulin resistance (IR) and metabolic syndrome (MetS), which is increasingly being viewed as an inflammatory disease. Thus, we examined the associations of serum ferritin with insulin resistance and MetS in postmenopausal women. METHODS: A nationwide cross-sectional study was conducted to examine the relationship between serum ferritin and IR and MetS in 2734 postmenopausal women using data from the 2010-2012 Korean National Health and Nutrition Examination Survey. The odds ratios (ORs) and 95% confidence intervals (CIs) for insulin resistance (HOMA-IR≥75th percentile, 3.04) and MetS were calculated using multiple logistic regression analyses across serum ferritin quartiles (Q1,≤36.25; Q2, 36.56-56.56; Q3, 56.57-85.98; and Q4≥85.99ng/ml). RESULTS: The mean values of most cardiometabolic variables tended to increase proportionally with serum ferritin quartiles. The proportion of women with IR and MetS significantly increased in accordance with serum ferritin quartiles. Compared to individuals in the lowest quartile, the ORs (95% CIs) in the highest quartile were 2.06 (1.23-3.45) for IR and 1.92 (1.44-2.55) for MetS after adjusting for age, cigarette smoking, alcohol intake, and regular exercise. CONCLUSION: Serum ferritin levels were positively and independently associated with IR and MetS in postmenopausal women. These findings suggest that serum ferritin level in postmenopausal women may help to identify the presence of IR and MetS.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Park, Jin-Kyung(박진경) ORCID logo https://orcid.org/0000-0002-3934-8632
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Cho, Mi Ra(조미라)
Cho, A Ra(조아라) ORCID logo https://orcid.org/0000-0002-3645-2282
Choi, Won Jun(최원준) ORCID logo https://orcid.org/0000-0002-8233-9272
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