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Vibration-induced nystagmus in patients with vestibular schwannoma: Characteristics and clinical implications

Authors
 Jeon Mi Lee  ;  Mi Joo Kim  ;  Jin Won Kim  ;  Dae Bo Shim  ;  Jinna Kim  ;  Sung Huhn Kim 
Citation
 Clinical Neurophysiology, Vol.128(7) : 1372-1379, 2017 
Journal Title
 Clinical Neurophysiology 
ISSN
 1388-2457 
Issue Date
2017
MeSH
Adult ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Mastoid/physiology ; Middle Aged ; Neuroma, Acoustic/diagnostic imaging* ; Neuroma, Acoustic/physiopathology* ; Nystagmus, Pathologic/diagnostic imaging* ; Nystagmus, Pathologic/etiology ; Nystagmus, Pathologic/physiopathology* ; Tumor Burden/physiology ; Vibration/adverse effects*
Keywords
Nystagmus ; Vestibular loss ; Vestibular schwannoma ; Vibration
Abstract
OBJECTIVE: To investigate the clinical significance of vibration-induced nystagmus (VIN) in unilateral vestibular asymmetry and vestibular schwannoma. METHODS: Thirteen patients with vestibular schwannoma underwent the VIN test, in which stimulation was applied to the mastoid processes and sternocleidomastoid (SCM) muscles on the ipsilateral and contralateral sides of lesions. Preoperative VIN was measured, and changes in VIN were followed up for 6months after tumor removal. Significance of VIN was determined by evaluation of its sensitivity, correlation with vestibular function tests and tumor volume, and postoperative changes. RESULTS: The overall pre and postoperative sensitivities of VIN were 92.3% and 100%, respectively, considering stimulation at all four sites. Maximum slow-phase velocity (MSPV) of VIN was linearly correlated with caloric weakness and tumor volume, especially when stimulation was applied to the SCM muscle. Postoperative MSPV of VIN exhibited stronger linear correlation with postoperative changes in canal paresis value and inverse correlation with tumor size upon stimulation of the ipsilateral SCM muscle than upon stimulation of other sites. During the 6-month follow-up period, persistence of VIN without changes in MSPV was observed even after vestibular compensation. CONCLUSIONS: Evoking VIN by stimulation of the mastoid processes and SCM muscles is effective for detecting vestibular asymmetry. It could also help determine the degree of vestibular asymmetry and volume of vestibular schwannoma if stimulation is applied to the SCM muscle. SIGNIFICANCE: The results of this study could provide clues for the basic application of VIN in patients with vestibular loss and vestibular schwannoma.
Full Text
https://www.sciencedirect.com/science/article/pii/S138824571730086X
DOI
10.1016/j.clinph.2017.02.023
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Huhn(김성헌)
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Kim, Jin Won(김진원)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160528
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