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Impaired prefrontal cognitive control over interference by food images in binge-eating disorder and bulimia nervosa

Authors
 Jung Eun Lee  ;  Kee Namkoong  ;  Young-Chul Jung 
Citation
 NEUROSCIENCE LETTERS, Vol.651 : 95-101, 2017 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
2017
MeSH
Adult ; Binge-Eating Disorder/physiopathology ; Binge-Eating Disorder/psychology ; Brain/physiopathology ; Brain Mapping ; Bulimia Nervosa/physiopathology ; Bulimia Nervosa/psychology ; Executive Function/physiology ; Female ; Food ; Humans ; Magnetic Resonance Imaging ; Motor Cortex/physiopathology ; Neostriatum/physiopathology ; Pilot Projects ; Prefrontal Cortex/physiopathology ; Stroop Test ; Ventral Striatum/physiopathology ; Visual Perception ; Young Adult
Keywords
Binge-eating disorder ; Bulimia nervosa ; Habit formation ; Reward sensitivity
Abstract
Binge-eating disorder (BED)characterized by recurrent episodes of binge-eating without inappropriate compensatory behaviors is classified as an official diagnosis in DSM-5. However, the neural bases that differentiate BED from other eating disorders such as bulimia nervosa (BN), are still under debate. Thirty-nine participants (HC, n=14; BN, n=13; BED, n=12) underwent functional MRI while performing a Stroop-Match-to-Sample task. This pilot study investigated how food images interfered with the behavioral performances and blood-oxygenation-level-dependent neuronal activity. Compared to healthy controls, participants with BN showed lower accuracy indicating impaired cognitive control over interference. Compared to healthy controls, participants with BED demonstrated stronger activations in the ventral striatum in response to food images. By contrast, participants with BN exhibited stronger activations in the premotor cortex and dorsal striatum. These aberrant ventral and dorsal frontostriatal activations in response to food images are associated with increased reward sensitivity and habitual binge-eating/purging behaviors in BED and BN.
Full Text
https://www.sciencedirect.com/science/article/pii/S030439401730366X
DOI
10.1016/j.neulet.2017.04.054
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Lee, Jung Eun(이정은)
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160516
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