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Cocaine inhibits leptin-induced increase of the cocaine- and amphetamine-regulated transcript peptide in the nucleus accumbens in rats

Authors
 Cho Bo Ram  ;  Yoon Hyung Shin  ;  Kim Wha Young  ;  Vezina Paul  ;  Kim Jeong-Hoon 
Citation
 NEUROREPORT, Vol.28(11) : 701-704, 2017 
Journal Title
NEUROREPORT
ISSN
 0959-4965 
Issue Date
2017
MeSH
Animals ; Cocaine/pharmacology ; Leptin/pharmacology ; Male ; Microinjections ; Motor Activity/drug effects ; Nerve Tissue Proteins/metabolism ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Rats, Sprague-Dawley
Abstract
Two well-known appetite-regulatory peptides, leptin and cocaine- and amphetamine-regulated transcript (CART), are known to be involved in the brain rewarding pathway. However, it is not yet known how they interact in the nucleus accumbens, an important region mediating the rewarding effects of drugs of abuse. Using the immunoassay method, we found that a microinjection of leptin into the nucleus accumbens core induces an immediate and transient increase of the CART peptide in this site, whereas these effects were inhibited by cocaine. These results expand the role of accumbal leptin to the regulation of the CART peptide and further suggest that possible interaction of these appetite-regulating peptides may be involved in cocaine-mediated rewarding effects.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201708020-00004&D=ovft&PDF=y
DOI
10.1097/WNR.0000000000000822
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Hoon(김정훈) ORCID logo https://orcid.org/0000-0001-7095-3729
Kim, Wha Young(김화영) ORCID logo https://orcid.org/0000-0003-1744-7012
Yoon, Hyung Shin(윤형신) ORCID logo https://orcid.org/0000-0003-4389-7578
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160471
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