Cited 2 times in
Cocaine inhibits leptin-induced increase of the cocaine- and amphetamine-regulated transcript peptide in the nucleus accumbens in rats
DC Field | Value | Language |
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dc.contributor.author | 김정훈 | - |
dc.contributor.author | 김화영 | - |
dc.contributor.author | 윤형신 | - |
dc.date.accessioned | 2018-07-20T07:44:02Z | - |
dc.date.available | 2018-07-20T07:44:02Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160471 | - |
dc.description.abstract | Two well-known appetite-regulatory peptides, leptin and cocaine- and amphetamine-regulated transcript (CART), are known to be involved in the brain rewarding pathway. However, it is not yet known how they interact in the nucleus accumbens, an important region mediating the rewarding effects of drugs of abuse. Using the immunoassay method, we found that a microinjection of leptin into the nucleus accumbens core induces an immediate and transient increase of the CART peptide in this site, whereas these effects were inhibited by cocaine. These results expand the role of accumbal leptin to the regulation of the CART peptide and further suggest that possible interaction of these appetite-regulating peptides may be involved in cocaine-mediated rewarding effects. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cocaine/pharmacology | - |
dc.subject.MESH | Leptin/pharmacology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microinjections | - |
dc.subject.MESH | Motor Activity/drug effects | - |
dc.subject.MESH | Nerve Tissue Proteins/metabolism | - |
dc.subject.MESH | Nucleus Accumbens/drug effects | - |
dc.subject.MESH | Nucleus Accumbens/metabolism | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.title | Cocaine inhibits leptin-induced increase of the cocaine- and amphetamine-regulated transcript peptide in the nucleus accumbens in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Physiology | - |
dc.contributor.googleauthor | Cho Bo Ram | - |
dc.contributor.googleauthor | Yoon Hyung Shin | - |
dc.contributor.googleauthor | Kim Wha Young | - |
dc.contributor.googleauthor | Vezina Paul | - |
dc.contributor.googleauthor | Kim Jeong-Hoon | - |
dc.identifier.doi | 10.1097/WNR.0000000000000822 | - |
dc.contributor.localId | A00908 | - |
dc.contributor.localId | A01198 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 28614180 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201708020-00004&D=ovft&PDF=y | - |
dc.contributor.alternativeName | Kim, Jeong Hoon | - |
dc.contributor.alternativeName | Kim, Wha Young | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Wha Young | - |
dc.citation.volume | 28 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 701 | - |
dc.citation.endPage | 704 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.28(11) : 701-704, 2017 | - |
dc.identifier.rimsid | 42307 | - |
dc.type.rims | ART | - |
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