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Serum persistent organic pollutants (POPs) and prostate cancer risk: A case-cohort study

Authors
 Jung-eun Lim  ;  Chungmo Nam  ;  Jiyeon Yang  ;  Koon Ho Rha  ;  Kyung-Min Lim  ;  Sun Ha Jee 
Citation
 INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol.220(5) : 849-856, 2017 
Journal Title
 INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 
ISSN
 1438-4639 
Issue Date
2017
MeSH
Adult ; Aged ; Cohort Studies ; Environmental Monitoring ; Environmental Pollutants/blood* ; Humans ; Hydrocarbons, Chlorinated/blood* ; Male ; Middle Aged ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/epidemiology* ; Prostatic Neoplasms/etiology ; Republic of Korea/epidemiology ; Risk
Keywords
Cohort studies ; Endocrine disruptors ; Polychlorinated biphenyls ; Prostatic neoplasms
Abstract
It is still unclear whether persistent organic pollutants (POPs) exposure increases the prostate cancer incidence risk. This prospective cohort study evaluated the associations between serum POPs concentrations and prostate cancer risk. Within a case-cohort study, we identified 110 people diagnosed with prostate cancer and randomly selected 256 sub-cohort participants without prostate cancer. Serum concentrations of 32 polychlorinated biphenyl (PCB) congeners and 19 organochlorine pesticides (OCPs) were measured. The hazard ratios (HRs) and 95% confidence interval (95% CI) for determining the associations between POPs and risk of prostate cancer were estimated using the weighted Cox regression model. Compared to the lowest tertile, increased risks of prostate cancer incidence were observed in the upper tertile of following PCBs: the moderately chlorinated (HR: 4.19; 95% CI: 1.30-13.54), the highly chlorinated (HR: 4.14; 95% CI: 1.75-9.79), biologically persistent as CYP1A and CYP2B inducers (HR: 4.44; 95% CI: 1.33-14.83), the sum of non- dioxin-like (HR: 3.47; 95% CI: 1.21-9.98), and ∑PCBs (HR: 4.29; 95% CI: 1.52-12.08). In dose-response curves, ∑PCBs was associated with the increased risk of prostate cancer. Our findings suggested a possible role of POPs in the etiology of prostate cancer.
Full Text
https://www.sciencedirect.com/science/article/pii/S1438463916305399
DOI
10.1016/j.ijheh.2017.03.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Environmental Research (환경공해연구소) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Yang, Ji Yeon(양지연)
Lim, Jung-eun(임정은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160432
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