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Beyond precision surgery: Molecularly motivated precision care for gastric cancer

Authors
 Y.Y. Choi  ;  J.-H. Cheong 
Citation
 EJSO, Vol.43(5) : 856-864, 2017 
Journal Title
EJSO
ISSN
 0748-7983 
Issue Date
2017
MeSH
Animals ; Disease Models, Animal ; Drug Resistance, Neoplasm/genetics ; Humans ; Molecular Targeted Therapy ; Patient-Specific Modeling ; Precision Medicine* ; Prognosis ; Stomach Neoplasms/genetics* ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy*
Keywords
Biology ; Classification ; Gastric cancer ; Patient-derived xenograft ; Precision medicine ; Preclinical model
Abstract
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Despite the high disease prevalence, gastric cancer research has not gained much attention. Recently, genome-scale technology has made it possible to explore the characteristics of gastric cancer at the molecular level. Accordingly, gastric cancer can be classified into molecular subtypes that convey more detailed information of tumor than histopathological characteristics, and these subtypes are associated with clinical outcomes. Furthermore, this molecular knowledge helps to identify new actionable targets and develop novel therapeutic strategies. To advance the concept of precision patient care in the clinic, patient-derived xenograft (PDX) models have recently been developed. PDX models not only represent histology and genomic features, but also predict responsiveness to investigational drugs in patient tumors. Molecularly curated PDX cohorts will be instrumental in hypothesis generation, biomarker discovery, and drug screening and testing in proof-of-concept preclinical trials for precision therapy. In the era of precision medicine, molecularly tailored therapeutic strategies should be individualized for cancer patients. To improve the overall clinical outcome, a multimodal approach is indispensable for advanced cancer patients. Careful, oncological principle-based surgery, combined with a molecularly guided multidisciplinary approach, will open new horizons in surgical oncology.
Full Text
https://www.sciencedirect.com/science/article/pii/S0748798317303608
DOI
10.1016/j.ejso.2017.02.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Choi, Yoon Young(최윤영) ORCID logo https://orcid.org/0000-0002-2179-7851
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160430
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