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Beyond precision surgery: Molecularly motivated precision care for gastric cancer

DC Field Value Language
dc.contributor.author정재호-
dc.contributor.author최윤영-
dc.date.accessioned2018-07-20T07:41:39Z-
dc.date.available2018-07-20T07:41:39Z-
dc.date.issued2017-
dc.identifier.issn0748-7983-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160430-
dc.description.abstractGastric cancer is one of the leading causes of cancer-related deaths worldwide. Despite the high disease prevalence, gastric cancer research has not gained much attention. Recently, genome-scale technology has made it possible to explore the characteristics of gastric cancer at the molecular level. Accordingly, gastric cancer can be classified into molecular subtypes that convey more detailed information of tumor than histopathological characteristics, and these subtypes are associated with clinical outcomes. Furthermore, this molecular knowledge helps to identify new actionable targets and develop novel therapeutic strategies. To advance the concept of precision patient care in the clinic, patient-derived xenograft (PDX) models have recently been developed. PDX models not only represent histology and genomic features, but also predict responsiveness to investigational drugs in patient tumors. Molecularly curated PDX cohorts will be instrumental in hypothesis generation, biomarker discovery, and drug screening and testing in proof-of-concept preclinical trials for precision therapy. In the era of precision medicine, molecularly tailored therapeutic strategies should be individualized for cancer patients. To improve the overall clinical outcome, a multimodal approach is indispensable for advanced cancer patients. Careful, oncological principle-based surgery, combined with a molecularly guided multidisciplinary approach, will open new horizons in surgical oncology.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfEJSO-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHDrug Resistance, Neoplasm/genetics-
dc.subject.MESHHumans-
dc.subject.MESHMolecular Targeted Therapy-
dc.subject.MESHPatient-Specific Modeling-
dc.subject.MESHPrecision Medicine*-
dc.subject.MESHPrognosis-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHStomach Neoplasms/therapy*-
dc.titleBeyond precision surgery: Molecularly motivated precision care for gastric cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorY.Y. Choi-
dc.contributor.googleauthorJ.-H. Cheong-
dc.identifier.doi10.1016/j.ejso.2017.02.013-
dc.contributor.localIdA03717-
dc.contributor.localIdA04138-
dc.relation.journalcodeJ00847-
dc.identifier.eissn1532-2157-
dc.identifier.pmid28330821-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0748798317303608-
dc.subject.keywordBiology-
dc.subject.keywordClassification-
dc.subject.keywordGastric cancer-
dc.subject.keywordPatient-derived xenograft-
dc.subject.keywordPrecision medicine-
dc.subject.keywordPreclinical model-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.alternativeNameChoi, Yoon Young-
dc.contributor.affiliatedAuthorCheong, Jae Ho-
dc.contributor.affiliatedAuthorChoi, Yoon Young-
dc.citation.volume43-
dc.citation.number5-
dc.citation.startPage856-
dc.citation.endPage864-
dc.identifier.bibliographicCitationEJSO, Vol.43(5) : 856-864, 2017-
dc.identifier.rimsid40599-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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