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Distribution and clinical significance of Mycobacterium avium complex species isolated from respiratory specimens

Authors
 Su-Young Kim  ;  Sun Hye Shin  ;  Seong Mi Moon  ;  Bumhee Yang  ;  Hojoong Kim  ;  O Jung Kwon  ;  Hee Jae Huh  ;  Chang-Seok Ki  ;  Nam Yong Lee  ;  Sung Jae Shin  ;  Won-Jung Koh 
Citation
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.88(2) : 125-137, 2017 
Journal Title
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
ISSN
 0732-8893 
Issue Date
2017
MeSH
Aged ; DNA, Bacterial/genetics ; Female ; Humans ; Lung Diseases/diagnosis* ; Lung Diseases/microbiology ; Male ; Middle Aged ; Multilocus Sequence Typing ; Mycobacterium avium/genetics* ; Mycobacterium avium/isolation & purification ; Mycobacterium avium Complex*/classification ; Mycobacterium avium Complex*/genetics ; Mycobacterium avium Complex*/isolation & purification ; Mycobacterium avium-intracellulare Infection/diagnosis* ; Mycobacterium avium-intracellulare Infection/microbiology
Keywords
Multilocus sequence typing ; Mycobacterium avium ; Mycobacterium avium complex ; Mycobacterium intracellulare
Abstract
Mycobacterium avium complex (MAC) was originally composed of 2 species, M. avium and M. intracellulare. However, several new species closely related to M. intracellulare have recently been identified. In addition, M. avium has been further subdivided into 4 subspecies. The aim of this study was to determine the proportion of different MAC species recovered from respiratory specimens and to elucidate the clinical relevance of these species. Clinical isolates, from 219 patients, that had been initially identified as M. avium or M. intracellulare by non-sequencing methods were reidentified using multilocus sequence typing, and the clinical significance of the identified species was then investigated. Of 91 isolates originally identified as M. intracellulare, 75 (82%) were confirmed to be M. intracellulare, 8 (9%) isolates were identified as M. chimaera, and 4 (4%) isolates each were identified as "M. indicus pranii" and M. yongonense. The 128 isolates originally designated as M. avium were determined to be M. avium subsp. hominissuis. Of the 219 patients, 146 (67%) met the diagnostic criteria for MAC lung disease, and for each MAC species, the proportion of patients meeting these criteria was as follows: M. intracellulare (54/75, 72%), M. chimaera (3/8, 38%), "M. indicus pranii" (3/4, 75%), M. yongonense (2/4, 50%), and M. avium subsp. hominissuis (84/128, 66%). In summary, multilocus sequence typing of respiratory isolates initially identified as MAC revealed that, although most isolates were M. avium subsp. hominissuis or M. intracellulare, approximately 7% were newer MAC members, with clinical evidence supporting their potential pathogenicity for humans.
Full Text
https://www.sciencedirect.com/science/article/pii/S0732889317300731
DOI
10.1016/j.diagmicrobio.2017.02.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160375
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