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Distribution and clinical significance of Mycobacterium avium complex species isolated from respiratory specimens

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dc.contributor.author신성재-
dc.date.accessioned2018-07-20T07:38:50Z-
dc.date.available2018-07-20T07:38:50Z-
dc.date.issued2017-
dc.identifier.issn0732-8893-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160375-
dc.description.abstractMycobacterium avium complex (MAC) was originally composed of 2 species, M. avium and M. intracellulare. However, several new species closely related to M. intracellulare have recently been identified. In addition, M. avium has been further subdivided into 4 subspecies. The aim of this study was to determine the proportion of different MAC species recovered from respiratory specimens and to elucidate the clinical relevance of these species. Clinical isolates, from 219 patients, that had been initially identified as M. avium or M. intracellulare by non-sequencing methods were reidentified using multilocus sequence typing, and the clinical significance of the identified species was then investigated. Of 91 isolates originally identified as M. intracellulare, 75 (82%) were confirmed to be M. intracellulare, 8 (9%) isolates were identified as M. chimaera, and 4 (4%) isolates each were identified as "M. indicus pranii" and M. yongonense. The 128 isolates originally designated as M. avium were determined to be M. avium subsp. hominissuis. Of the 219 patients, 146 (67%) met the diagnostic criteria for MAC lung disease, and for each MAC species, the proportion of patients meeting these criteria was as follows: M. intracellulare (54/75, 72%), M. chimaera (3/8, 38%), "M. indicus pranii" (3/4, 75%), M. yongonense (2/4, 50%), and M. avium subsp. hominissuis (84/128, 66%). In summary, multilocus sequence typing of respiratory isolates initially identified as MAC revealed that, although most isolates were M. avium subsp. hominissuis or M. intracellulare, approximately 7% were newer MAC members, with clinical evidence supporting their potential pathogenicity for humans.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Biomedical-
dc.relation.isPartOfDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHDNA, Bacterial/genetics-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLung Diseases/diagnosis*-
dc.subject.MESHLung Diseases/microbiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultilocus Sequence Typing-
dc.subject.MESHMycobacterium avium/genetics*-
dc.subject.MESHMycobacterium avium/isolation & purification-
dc.subject.MESHMycobacterium avium Complex*/classification-
dc.subject.MESHMycobacterium avium Complex*/genetics-
dc.subject.MESHMycobacterium avium Complex*/isolation & purification-
dc.subject.MESHMycobacterium avium-intracellulare Infection/diagnosis*-
dc.subject.MESHMycobacterium avium-intracellulare Infection/microbiology-
dc.titleDistribution and clinical significance of Mycobacterium avium complex species isolated from respiratory specimens-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Microbiology-
dc.contributor.googleauthorSu-Young Kim-
dc.contributor.googleauthorSun Hye Shin-
dc.contributor.googleauthorSeong Mi Moon-
dc.contributor.googleauthorBumhee Yang-
dc.contributor.googleauthorHojoong Kim-
dc.contributor.googleauthorO Jung Kwon-
dc.contributor.googleauthorHee Jae Huh-
dc.contributor.googleauthorChang-Seok Ki-
dc.contributor.googleauthorNam Yong Lee-
dc.contributor.googleauthorSung Jae Shin-
dc.contributor.googleauthorWon-Jung Koh-
dc.identifier.doi10.1016/j.diagmicrobio.2017.02.017-
dc.contributor.localIdA02114-
dc.relation.journalcodeJ00731-
dc.identifier.eissn1879-0070-
dc.identifier.pmid28291631-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0732889317300731-
dc.subject.keywordMultilocus sequence typing-
dc.subject.keywordMycobacterium avium-
dc.subject.keywordMycobacterium avium complex-
dc.subject.keywordMycobacterium intracellulare-
dc.contributor.alternativeNameShin, Sung Jae-
dc.contributor.affiliatedAuthorShin, Sung Jae-
dc.citation.volume88-
dc.citation.number2-
dc.citation.startPage125-
dc.citation.endPage137-
dc.identifier.bibliographicCitationDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.88(2) : 125-137, 2017-
dc.identifier.rimsid43534-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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