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Gadolinium deposition in the brain: association with various GBCAs using a generalized additive model

 Sohi Bae  ;  Ho-Joon Lee  ;  Kyunghwa Han  ;  Yae-Won Park  ;  Yoon Seong Choi  ;  Sung Soo Ahn  ;  Jinna Kim  ;  Seung-Koo Lee 
 EUROPEAN RADIOLOGY, Vol.27(8) : 3353-3361, 2017 
Journal Title
Issue Date
Aged ; Brain/diagnostic imaging* ; Brain/metabolism ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/secondary ; Cerebellar Nuclei/diagnostic imaging ; Cerebellar Nuclei/metabolism ; Contrast Media/administration & dosage ; Contrast Media/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Gadolinium/administration & dosage* ; Gadolinium/pharmacokinetics ; Gadolinium DTPA/administration & dosage ; Gadolinium DTPA/pharmacokinetics ; Globus Pallidus/diagnostic imaging ; Globus Pallidus/metabolism ; Glomerular Filtration Rate/drug effects ; Humans ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Observer Variation ; Organometallic Compounds ; Pons/diagnostic imaging ; Pons/metabolism ; Retrospective Studies ; Thalamus/diagnostic imaging ; Thalamus/metabolism
Contrast media ; Dentate nucleus ; Gadolinium ; Globus pallidus ; Magnetic resonance imaging
OBJECTIVES: To determine the relationship between the number of administrations of various gadolinium-based contrast agents (GBCAs) and increased T1 signal intensity in the globus pallidus (GP) and dentate nucleus (DN).

METHODS: This retrospective study included 122 patients who underwent double-dose GBCA-enhanced magnetic resonance imaging. Two radiologists calculated GP-to-thalamus (TH) signal intensity ratio, DN-to-pons signal intensity ratio and relative change (Rchange) between the baseline and final examinations. Interobserver agreement was evaluated. The relationships between Rchange and several factors, including number of each GBCA administrations, were analysed using a generalized additive model.

RESULTS: Six patients (4.9%) received linear GBCAs (mean 20.8 number of administration; range 15-30), 44 patients (36.1%) received macrocyclic GBCAs (mean 26.1; range 14-51) and 72 patients (59.0%) received both types of GBCAs (mean 31.5; range 12-65). Interobserver agreement was almost perfect (0.99; 95% CI: 0.99-0.99). Rchange (DN:pons) was associated with gadodiamide (p = 0.006) and gadopentetate dimeglumine (p < 0.001), but not with other GBCAs. Rchange (GP:TH) was not associated with GBCA administration.

CONCLUSIONS: Previous administration of linear agents gadoiamide and gadopentetate dimeglumine is associated with increased T1 signal intensity in the DN, whereas macrocyclic GBCAs do not show an association.

KEY POINTS: • Certain linear GBCAs are associated with T1 signal change in the dentate nucleus. • The signal change is related to the administration number of certain linear GBCAs. • Difference in signal change may reflect differences in stability of agents.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Park, Yae Won(박예원) ORCID logo https://orcid.org/0000-0001-8907-5401
Bae, Sohi(배소희)
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-0503-5558
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Ho Joon(이호준)
Choi, Yoon Seong(최윤성)
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