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Bone augmentation at peri-implant dehiscence defects comparing a synthetic polyethylene glycol hydrogel matrix vs. standard guided bone regeneration techniques

Authors
 Daniel S. Thoma  ;  Ui‐Won Jung  ;  Jin‐Young Park  ;  Stefan P. Bienz  ;  Jürg Hüsler  ;  Ronald E. Jung 
Citation
 Clinical Oral Implants Research, Vol.28(7) : e76-e83, 2017 
Journal Title
 Clinical Oral Implants Research 
ISSN
 0905-7161 
Issue Date
2017
Keywords
animal research ; bone ; bone regeneration ; bone substitutes ; dental implants ; guided tissue regeneration ; polyethylene glycols
Abstract
OBJECTIVES: The aim of the study was to test whether or not the use of a polyethylene glycol (PEG) hydrogel with or without the addition of an arginylglycylaspartic acid (RGD) sequence applied as a matrix in combination with hydroxyapatite/tricalciumphosphate (HA/TCP) results in similar peri-implant bone regeneration as traditional guided bone regeneration procedures. MATERIAL AND METHODS: In 12 beagle dogs, implant placement and peri-implant bone regeneration were performed 2 months after tooth extraction in the maxilla. Two standardized box-shaped defects were bilaterally created, and dental implants were placed in the center of the defects with a dehiscence of 4 mm. Four treatment modalities were randomly applied: i)HA/TCP mixed with a synthetic PEG hydrogel, ii)HA/TCP mixed with a synthetic PEG hydrogel supplemented with an RGD sequence, iii)HA/TCP covered with a native collagen membrane (CM), iv)and no bone augmentation (empty). After a healing period of 8 or 16 weeks, micro-CT and histological analyses were performed. RESULTS: Histomorphometric analysis revealed a greater relative augmented area for groups with bone augmentation (43.3%-53.9% at 8 weeks, 31.2%-42.8% at 16 weeks) compared to empty controls (22.9% at 8 weeks, 1.1% at 16 weeks). The median amount of newly formed bone was greatest in group CM at both time-points. Regarding the first bone-to-implant contact, CM was statistically significantly superior to all other groups at 8 weeks. CONCLUSIONS: Bone can partially be regenerated at peri-implant buccal dehiscence defects using traditional guided bone regeneration techniques. The use of a PEG hydrogel applied as a matrix mixed with a synthetic bone substitute material might lack a sufficient stability over time for this kind of defect.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/clr.12877
DOI
10.1111/clr.12877
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실)
Yonsei Authors
박진영(Park, Jin Young)
정의원(Jung, Ui Won) ORCID logo https://orcid.org/0000-0001-6371-4172
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160310
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