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Effects of Paraquat Ban on Herbicide Poisoning-Related Mortality.

Authors
 Dong Ryul K  ;  Sung Phil Chun  ;  Je Sung Yo  ;  Soohyung Ch  ;  Yongjin Par  ;  Byeongjo Chu  ;  Jeongmi Moo  ;  Hyun Ki  ;  Yong Hwan Ki  ;  Hyun Jin Ki  ;  Kyung-Woo Le  ;  SangChun Cho  ;  Junseok Par  ;  Jung Soo Par  ;  Seung Whan Ki  ;  Jeong Yeol Se  ;  Ha Young Par  ;  Su Jin Ki  ;  Hyunggoo Kan  ;  Dae Young Hon  ;  Jung Hwa Hong 
Citation
 Yonsei Medical Journal, Vol.58(4) : 859-866, 2017 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2017
MeSH
Bayes Theorem ; Demography ; Female ; Geography ; Herbicides/poisoning* ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Paraquat/poisoning* ; Poisoning/mortality* ; Republic of Korea
Keywords
Poisoning ; herbicides ; mortality ; paraquat
Abstract
PURPOSE: In Korea, registration of paraquat-containing herbicides was canceled in November 2011, and sales thereof were completely banned in November 2012. We evaluated the effect of the paraquat ban on the epidemiology and mortality of herbicide-induced poisoning. MATERIALS AND METHODS: This retrospective study analyzed patients treated for herbicide poisoning at 17 emergency departments in South Korea between January 2010 and December 2014. The overall and paraquat mortality rates were compared pre- and post-ban. Factors associated with herbicide mortality were evaluated using logistic analysis. To determine if there were any changes in the mortality rates before and after the paraquat sales ban and the time point of any such significant changes in mortality, R software, version 3.0.3 (package, bcp) was used to perform a Bayesian change point analysis. RESULTS: We enrolled 2257 patients treated for herbicide poisoning (paraquat=46.8%). The overall and paraquat poisoning mortality rates were 40.6% and 73.0%, respectively. The decreased paraquat poisoning mortality rate (before, 75% vs. after, 67%, p=0.014) might be associated with increased intentionality. The multivariable logistic analysis revealed the paraquat ban as an independent predictor that decreased herbicide poisoning mortality (p=0.035). There were two major change points in herbicide mortality rates, approximately 3 months after the initial paraquat ban and 1 year after complete sales ban. CONCLUSION: This study suggests that the paraquat ban decreased intentional herbicide ingestion and contributed to lowering herbicide poisoning-associated mortality. The change point analysis suggests a certain timeframe was required for the manifestation of regulatory measures outcomes.
Files in This Item:
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DOI
10.3349/ymj.2017.58.4.859
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
고동률(Ko, Dong Ryul) ORCID logo https://orcid.org/0000-0002-3098-2784
유제성(You, Je Sung) ORCID logo https://orcid.org/0000-0002-2074-6745
정성필(Chung, Sung Pil) ORCID logo https://orcid.org/0000-0002-3074-011X
홍정화(Hong, Jung Hwa)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160267
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