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Taurolidine: a new alternative agent for the management of the postoperative air leak

Authors
 Chun Sung Byun  ;  In Kyu Park  ;  Hyo Sup Shim  ;  Mi Kyung Bae  ;  Chang Young Lee  ;  Kyung Young Chung 
Citation
 ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, Vol.19(1) : 6-11, 2013 
Journal Title
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
ISSN
 1341-1098 
Issue Date
2013
MeSH
Adult ; Aged ; Aged, 80 and over ; Animals ; Chest Tubes ; Female ; Humans ; Lung/diagnostic imaging ; Lung/drug effects ; Lung/physiopathology ; Male ; Middle Aged ; Models, Animal ; Pleura/drug effects ; Pleura/pathology ; Pleurodesis/methods ; Pneumothorax/diagnostic imaging ; Pneumothorax/etiology ; Pneumothorax/physiopathology ; Pneumothorax/therapy ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/etiology ; Postoperative Complications/physiopathology ; Postoperative Complications/therapy ; Rabbits ; Radiography ; Retrospective Studies ; Sclerosing Solutions/administration & dosage ; Talc/administration & dosage ; Taurine/administration & dosage ; Taurine/analogs & derivatives ; Thiadiazines/administration & dosage ; Time Factors ; Treatment Outcome ; Young Adult
Abstract
PURPOSE: To evaluate the efficacy of taurolidine instillation on postoperative air leak by clinical study and to investigate the mechanism of action by animal experiments. METHODS: Outcomes of taurolidine instillation in patients with postoperative air leak were retrospectively reviewed. 100 ml of 1% taurolidine solution was instilled through a chest tube in patients with postoperative air leak lasting 4days or more. Success was defined as cessation of air leak within 24 hours with full expansion of lung on chest radiograph and subsequent removal of chest tube within another 24 hours. The effect of taurolidine instillation was estimated by development of adhesion and thickening of the visceral pleura in rabbits. The study group was compared with a control group and a talc poudrage group. RESULTS: Out of 75 patients, the success rate was 66.7%. Out of 96 total attempts, taurolidine instillation was successful in 55%. In animal experiments, pleural adhesion was minimal in the taurolidine and control groups, whereas the talc group showed more adhesions. The taurolidine group showed a moderate visceral pleural thickening. The talc group showed severe visceral pleural thickening, whereas the control group showed mild thickening. CONCLUSION: Taurolidine is an effective alternative agent for the management of air leak. A chemical sclerosing effect is suggested as the mechanism of air leak cessation.
Files in This Item:
T201306356.pdf Download
DOI
10.5761/atcs.oa.11.01875
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
Lee, Chang Young(이창영)
Chung, Kyung Young(정경영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158546
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