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Taurolidine: a new alternative agent for the management of the postoperative air leak

DC Field Value Language
dc.contributor.author심효섭-
dc.contributor.author이창영-
dc.contributor.author정경영-
dc.date.accessioned2018-05-10T06:44:25Z-
dc.date.available2018-05-10T06:44:25Z-
dc.date.issued2013-
dc.identifier.issn1341-1098-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158546-
dc.description.abstractPURPOSE: To evaluate the efficacy of taurolidine instillation on postoperative air leak by clinical study and to investigate the mechanism of action by animal experiments. METHODS: Outcomes of taurolidine instillation in patients with postoperative air leak were retrospectively reviewed. 100 ml of 1% taurolidine solution was instilled through a chest tube in patients with postoperative air leak lasting 4days or more. Success was defined as cessation of air leak within 24 hours with full expansion of lung on chest radiograph and subsequent removal of chest tube within another 24 hours. The effect of taurolidine instillation was estimated by development of adhesion and thickening of the visceral pleura in rabbits. The study group was compared with a control group and a talc poudrage group. RESULTS: Out of 75 patients, the success rate was 66.7%. Out of 96 total attempts, taurolidine instillation was successful in 55%. In animal experiments, pleural adhesion was minimal in the taurolidine and control groups, whereas the talc group showed more adhesions. The taurolidine group showed a moderate visceral pleural thickening. The talc group showed severe visceral pleural thickening, whereas the control group showed mild thickening. CONCLUSION: Taurolidine is an effective alternative agent for the management of air leak. A chemical sclerosing effect is suggested as the mechanism of air leak cessation.-
dc.description.statementOfResponsibilityopen-
dc.languageJapan-
dc.publisher2186-1005-
dc.relation.isPartOfANNALS OF THORACIC AND CARDIOVASCULAR SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnimals-
dc.subject.MESHChest Tubes-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLung/diagnostic imaging-
dc.subject.MESHLung/drug effects-
dc.subject.MESHLung/physiopathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHModels, Animal-
dc.subject.MESHPleura/drug effects-
dc.subject.MESHPleura/pathology-
dc.subject.MESHPleurodesis/methods-
dc.subject.MESHPneumothorax/diagnostic imaging-
dc.subject.MESHPneumothorax/etiology-
dc.subject.MESHPneumothorax/physiopathology-
dc.subject.MESHPneumothorax/therapy-
dc.subject.MESHPostoperative Complications/diagnostic imaging-
dc.subject.MESHPostoperative Complications/etiology-
dc.subject.MESHPostoperative Complications/physiopathology-
dc.subject.MESHPostoperative Complications/therapy-
dc.subject.MESHRabbits-
dc.subject.MESHRadiography-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSclerosing Solutions/administration & dosage-
dc.subject.MESHTalc/administration & dosage-
dc.subject.MESHTaurine/administration & dosage-
dc.subject.MESHTaurine/analogs & derivatives-
dc.subject.MESHThiadiazines/administration & dosage-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleTaurolidine: a new alternative agent for the management of the postoperative air leak-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorChun Sung Byun-
dc.contributor.googleauthorIn Kyu Park-
dc.contributor.googleauthorHyo Sup Shim-
dc.contributor.googleauthorMi Kyung Bae-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorKyung Young Chung-
dc.identifier.doi10.5761/atcs.oa.11.01875-
dc.contributor.localIdA02219-
dc.contributor.localIdA03245-
dc.contributor.localIdA03571-
dc.relation.journalcodeJ03282-
dc.identifier.eissn2186-1005-
dc.identifier.pmid22785451-
dc.contributor.alternativeNameShim, Hyo Sup-
dc.contributor.alternativeNameLee, Chang Young-
dc.contributor.alternativeNameChung, Kyung Young-
dc.contributor.affiliatedAuthorShim, Hyo Sup-
dc.contributor.affiliatedAuthorLee, Chang Young-
dc.contributor.affiliatedAuthorChung, Kyung Young-
dc.citation.volume19-
dc.citation.number1-
dc.citation.startPage6-
dc.citation.endPage11-
dc.identifier.bibliographicCitationANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, Vol.19(1) : 6-11, 2013-
dc.identifier.rimsid43136-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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