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The Therapeutic Potential of Apoptosis Signal-Regulating

Authors
 So Yeong Cheon  ;  Kyoung Joo Cho  ;  Jong Eun Lee  ;  Gyung Whan Kim 
Citation
 Vascular Neurology, Vol.5 : 3-6, 2013 
Journal Title
 Vascular Neurology 
ISSN
 2092-6855 
Issue Date
2013
Keywords
Ischemic stroke ; Cerebral ischemia ; Apoptosis signal-regulating kinase 1
Abstract
Stroke is a worldwide social and economical issue. Ischemic stroke occupies 85 percent of stroke patients and they suffer from disability and other complications such as dementia and paralysis. Despites intensive efforts to rescue stroke patients and expand time window, clinical therapy is limited yet. As well as advanced established method, we need develop novel therapeutic targets for treating ischemic stroke. Apotosis signal-regulating kinase 1 (ASK1) is a member of mitogen activated protein kinase kinase kinase family. ASK1 activates mitogen activated protein kinase kinase and mitogen activated protein kinase family, which is important role in intracellular signaling after various insults from extracellular to intracellular stimuli such as oxidative stress, endoplasmic reticulum stress, osmolality changes and bacterial infection. These are also pathophysiologic factors of cerebral ischemia. In animal model of ischemic stroke, ASK1 is activated under ischemiainduced oxidative stress and apoptosis. ASK1 by silencing with small interfering RNA significantly decreased infarct volume and neuronal cell death. Based on several basic researches, we carefully suggest that inhibition of ASK1 is a novel approach for ischemic stroke therapy.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Gyung Whan(김경환) ORCID logo https://orcid.org/0000-0001-7053-4372
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
Cheon, So Yeong(전소영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158397
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