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Melatonin Improves Cognitive Impairment in Alzheimer’s Disease

 Juhyun Song  ;  Kyung Ah Park  ;  Won Taek Lee  ;  Kyoung Min Lee  ;  Jong Eun Lee 
 Vascular Neurology, Vol.5 : 7-11, 2013 
Journal Title
Vascular Neurology
Issue Date
Melatonin ; Alzheimer’s disease ; Amyloid beta ; Insulin resistance ; Cognitive impairment
Melatonin is synthesized in the pineal gland, retina, and organs. Melatonin has a variety of physiological functions on free radicals, circadian rhythms, immune system. In addition, melatonin is relevant for various pathologies in central nervous system disorders such as cerebral ischemia and Alzheimer’s disease (AD). Particularly, AD has hallmarks including both aggregation of senile plaques derived from amyloid beta peptides and neurofibrillary tangles, especially in hippocampus or cerebral cortex relevant to learning and memory. In addition, insulin signal dysfunction resulted in cognitive decline is a typical pathology in AD brain. Decreased melatonin in cerebrospinal
fluid is observed in AD patients. Melatonin has the ability to regulate amyloid precursor protein metabolism and prevent Aβ pathology. Moreover, melatonin is involved in insulin secretion in animals and humans and melatonin receptor deficiency influences insulin resistance in brain. In conclusion, melatonin contributes to improvement of learning and memory processing in AD. Thus, melatonin may serve as a potential therapeutic factor for cognitive decline in AD. Here, we aim to summarize recent studies that suggest the relationship between melatonin and cognitive impairment in AD.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Ah(박경아)
Song, Ju Hyun(송주현)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
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