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Non-high-density Lipoprotein Cholesterol is a good indicator of Pulse Wave Velocity rather than Low-density Lipoprotein Cholesterol in asymptomatic individuals

Authors
 Seon-Young Kwon  ;  You-Na Son  ;  Ji-Won Lee  ;  Jong-Koo Kim 
Citation
 Journal of Lifestyle Medicine, Vol.2(1) : 41-46, 2012 
Journal Title
 Journal of Lifestyle Medicine 
ISSN
 2234-8549 
Issue Date
2012
Keywords
Pulse wave velocity ; Atherosclerosis ; Lipoproteins ; Non-high density lipoprotein cholesterol
Abstract
Although targeting low-density lipoprotein cholesterol (LDL-C) has been a primary goal of lipid lowering therapy, a few growing evidences show that non-high-density lipoprotein cholesterol (Non-HDL-C) is a strong, independent predictor of cardiovascular disease nowadays. But few studies have assessed the association between conventional lipoproteins and subclinical atherosclerosis. We analyzed the association of Non-HDL-C, LDL-C with brachial-ankle pulse wave velocity (baPWV), a marker of subclinical atherosclerosis. We studied 766 apparently healthy individuals who checked baPWV. We analyzed P for trend for the association between baPWV and quartiles of Non-HDL-C, LDL-C. Multivariate analysis was used between quartiles of each lipoprotein and baPWV after adjustment for confounding variables. BaPWV shows increased trend across increase quartiles of Non-HDL-C and LDL-C, with statistical significance only in Non-HDL-C. In a multiple regression model, pulse wave velocity was positively correlated with Non-HDL-C and LDL-C. The relationship remained in Non-HDL-C after adjustment of LDL-C. However, in LDL-C, the relationship was vanished after adjustment of Non-HDL-C. In this study Non-HDL-C was more strongly associated with baPWV than LDL-C. These data suggests that Non-HDL-C may be an important treatment target in the prevention of cardiovascular disease.
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DOI
10.15280/jlm.2012.2.1.41
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
이지원(Lee, Ji Won) ORCID logo https://orcid.org/0000-0002-2666-4249
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158258
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