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Non-high-density Lipoprotein Cholesterol is a good indicator of Pulse Wave Velocity rather than Low-density Lipoprotein Cholesterol in asymptomatic individuals
DC Field | Value | Language |
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dc.contributor.author | 이지원 | - |
dc.date.accessioned | 2018-05-10T06:35:35Z | - |
dc.date.available | 2018-05-10T06:35:35Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2234-8549 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/158258 | - |
dc.description.abstract | Although targeting low-density lipoprotein cholesterol (LDL-C) has been a primary goal of lipid lowering therapy, a few growing evidences show that non-high-density lipoprotein cholesterol (Non-HDL-C) is a strong, independent predictor of cardiovascular disease nowadays. But few studies have assessed the association between conventional lipoproteins and subclinical atherosclerosis. We analyzed the association of Non-HDL-C, LDL-C with brachial-ankle pulse wave velocity (baPWV), a marker of subclinical atherosclerosis. We studied 766 apparently healthy individuals who checked baPWV. We analyzed P for trend for the association between baPWV and quartiles of Non-HDL-C, LDL-C. Multivariate analysis was used between quartiles of each lipoprotein and baPWV after adjustment for confounding variables. BaPWV shows increased trend across increase quartiles of Non-HDL-C and LDL-C, with statistical significance only in Non-HDL-C. In a multiple regression model, pulse wave velocity was positively correlated with Non-HDL-C and LDL-C. The relationship remained in Non-HDL-C after adjustment of LDL-C. However, in LDL-C, the relationship was vanished after adjustment of Non-HDL-C. In this study Non-HDL-C was more strongly associated with baPWV than LDL-C. These data suggests that Non-HDL-C may be an important treatment target in the prevention of cardiovascular disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University Wonju College of Medicine | - |
dc.relation.isPartOf | Journal of Lifestyle Medicine | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Non-high-density Lipoprotein Cholesterol is a good indicator of Pulse Wave Velocity rather than Low-density Lipoprotein Cholesterol in asymptomatic individuals | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Family Medicine | - |
dc.contributor.googleauthor | Seon-Young Kwon | - |
dc.contributor.googleauthor | You-Na Son | - |
dc.contributor.googleauthor | Ji-Won Lee | - |
dc.contributor.googleauthor | Jong-Koo Kim | - |
dc.identifier.doi | 10.15280/jlm.2012.2.1.41 | - |
dc.contributor.localId | A03203 | - |
dc.relation.journalcode | J01561 | - |
dc.identifier.eissn | 2288-1557 | - |
dc.subject.keyword | Pulse wave velocity | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Lipoproteins | - |
dc.subject.keyword | Non-high density lipoprotein cholesterol | - |
dc.contributor.alternativeName | Lee, Ji Won | - |
dc.contributor.affiliatedAuthor | Lee, Ji Won | - |
dc.citation.volume | 2 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 41 | - |
dc.citation.endPage | 46 | - |
dc.identifier.bibliographicCitation | Journal of Lifestyle Medicine, Vol.2(1) : 41-46, 2012 | - |
dc.identifier.rimsid | 40642 | - |
dc.type.rims | ART | - |
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