148 424

Cited 34 times in

Randomized clinical trial on the efficacy of Escherichia coli- derived rhBMP-2 with β-TCP/HA in extraction socket

Authors
 Jung-Bo Huh  ;  Hyo-Jung Lee  ;  Ji-Woong Jang  ;  Myung-Jin Kim  ;  Pil-Young Yun  ;  Su-Hong Kim  ;  Kyung-Hee Choi  ;  Young-Kyun Kim  ;  Kyoo-Sung Cho  ;  Sang-Wan Shin 
Citation
 JOURNAL OF ADVANCED PROSTHODONTICS, Vol.3(3) : 161-165, 2011 
Journal Title
JOURNAL OF ADVANCED PROSTHODONTICS
ISSN
 2005-7806 
Issue Date
2011
Keywords
Alveolar bone regeneration ; ErhBMP-2 ; Randomized clinical trial ; Tooth extraction ; β-TCP/HA
Abstract
PURPOSE : This randomized clinical trial was conducted to assess the safety and effectiveness of the ErhBMP-2 in alveolar bone regeneration as well as preservation of the β-TCP bone graft material that contains ErhBMP-2.

MATERIALS AND METHODS : This study involved 72 patients at the 3 study centers. The patients, who were divided into 2 groups: the experiment group who had ErhBMP-2 coated TCP/HA and the control group who had TCP/HA graft material alone transplanted immediately after tooth extraction. CT was taken before and 3 months after the transplantation and healing status was compared between the two groups. The efficacy endpoints that were used to measure the degree of bone induction included alveolar bone height and 3 measurements of bone width. The paired t test was used to determine the significance of the changes (P<.05).

RESULTS : Changes in alveolar bone height were -1.087 ± 1.413 mm in the control group and -.059 ± 0.960 mm in the experimental group (P<.01). At 25% extraction socket length [ESL], the changes were 0.006 ± 1.149 mm in the control group and 1.279 ± 1.387 mm in the experimental group. At 50% ESL, the changes were 0.542 ± 1.157 mm and 1.239 ± 1.249 mm, respectively (P<.01 for 25% ESL, and P<.05 for 50% ESL). During the experiment, no adverse reactions to the graft material were observed.

CONCLUSION : ErhBMP-2 coated β-TCP/HA were found to be more effective in preserving alveolar bone than conventional β-TCP/HA alloplastic bone graft materials.
Files in This Item:
T201194493.pdf Download
DOI
10.4047/jap.2011.3.3.161
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158201
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links