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Epigallocatechin-3-O-Gallate-Loaded Poly(lactic-co-glycolic acid) Fibrous Sheets as Anti-Adhesion Barriers

 Lee Jong Ho  ;  Shin Yong Cheol  ;  Yang Won Jun  ;  Park Jong-Chul  ;  Hyon Suong-Hyu  ;  Han Dong-Wook 
 Journal of Biomedical Nanotechnology, Vol.11(8) : 1461-1471, 2015 
Journal Title
 Journal of Biomedical Nanotechnology 
Issue Date
Adsorption ; Animals ; Antioxidants/administration & dosage ; Antioxidants/chemistry ; Bandages* ; Catechin/administration & dosage ; Catechin/analogs & derivatives* ; Catechin/chemistry ; Lactic Acid/chemistry* ; Male ; Materials Testing ; Nanocapsules/chemistry* ; Nanocapsules/ultrastructure ; Polyglycolic Acid/chemistry* ; Rats ; Rats, Sprague-Dawley ; Surface Properties ; Tissue Adhesions/drug therapy* ; Tissue Adhesions/pathology ; Treatment Outcome
Epigallocatechin-3-O-gallate (EGCG), the main polyphenolic component of green tea, has a wide range of pharmacological activities, including antioxidant, anti-inflammatory, and anti-fibrotic effects. In this study, EGCG-loaded poly(lactic-co-glycolic acid) (PLGA) sheets were prepared by electrospinning nanofibers and evaluating their potential as tissue-adhesion barriers. EGCG-loaded PLGA (E-PLGA) fibrous sheets were electrospun from a PLGA solution containing 8% (w/v) EGCG. The average diameter of E-PLGA fibers was 397 ± 159 nm, which was comparable to that of pure PLGA fibers (459 ± 154 nm). EGCG was uniformly dispersed in E-PLGA sheets without direct chemical interactions. E-PLGA fibrous sheets showed sustained release of EGCG by controlled diffusion and PLGA degradation. The attachment and proliferation of L-929 fibroblastic cells were significantly (p < 0.05) suppressed in E-PLGA sheets. Furthermore, E-PLGA fibrous sheets did not induce any inflammatory response to J774A.1 macrophages. The anti-adhesion efficacy of E-PLGA fibrous sheets was evaluated in the intraperitoneal adhesion model in rats. Two weeks after surgical treatment, macroscopic adhesion (extent and severity) scores and histopathological tissue responses of E-PLGA fibrous sheets were significantly lower than those of non-treated controls and pure PLGA sheets. The results suggest that the scores are comparable, and in some cases superior, to those of other commercialized tissue-adhesion barriers. In conclusion, our study findings suggest that E-PLGA fibrous sheets may be exploited as potential tissue-adhesion barriers for the prevention of post-surgical adhesion formation.
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1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
박종철(Park, Jong Chul) ORCID logo https://orcid.org/0000-0003-0083-5991
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