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Epigallocatechin-3-O-Gallate-Loaded Poly(lactic-co-glycolic acid) Fibrous Sheets as Anti-Adhesion Barriers

DC FieldValueLanguage
dc.contributor.author박종철-
dc.date.accessioned2018-03-26T17:11:27Z-
dc.date.available2018-03-26T17:11:27Z-
dc.date.issued2015-
dc.identifier.issn1550-7033-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157316-
dc.description.abstractEpigallocatechin-3-O-gallate (EGCG), the main polyphenolic component of green tea, has a wide range of pharmacological activities, including antioxidant, anti-inflammatory, and anti-fibrotic effects. In this study, EGCG-loaded poly(lactic-co-glycolic acid) (PLGA) sheets were prepared by electrospinning nanofibers and evaluating their potential as tissue-adhesion barriers. EGCG-loaded PLGA (E-PLGA) fibrous sheets were electrospun from a PLGA solution containing 8% (w/v) EGCG. The average diameter of E-PLGA fibers was 397 ± 159 nm, which was comparable to that of pure PLGA fibers (459 ± 154 nm). EGCG was uniformly dispersed in E-PLGA sheets without direct chemical interactions. E-PLGA fibrous sheets showed sustained release of EGCG by controlled diffusion and PLGA degradation. The attachment and proliferation of L-929 fibroblastic cells were significantly (p < 0.05) suppressed in E-PLGA sheets. Furthermore, E-PLGA fibrous sheets did not induce any inflammatory response to J774A.1 macrophages. The anti-adhesion efficacy of E-PLGA fibrous sheets was evaluated in the intraperitoneal adhesion model in rats. Two weeks after surgical treatment, macroscopic adhesion (extent and severity) scores and histopathological tissue responses of E-PLGA fibrous sheets were significantly lower than those of non-treated controls and pure PLGA sheets. The results suggest that the scores are comparable, and in some cases superior, to those of other commercialized tissue-adhesion barriers. In conclusion, our study findings suggest that E-PLGA fibrous sheets may be exploited as potential tissue-adhesion barriers for the prevention of post-surgical adhesion formation.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Scientific Publishers-
dc.relation.isPartOfJOURNAL OF BIOMEDICAL NANOTECHNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdsorption-
dc.subject.MESHAnimals-
dc.subject.MESHAntioxidants/administration & dosage-
dc.subject.MESHAntioxidants/chemistry-
dc.subject.MESHBandages*-
dc.subject.MESHCatechin/administration & dosage-
dc.subject.MESHCatechin/analogs & derivatives*-
dc.subject.MESHCatechin/chemistry-
dc.subject.MESHLactic Acid/chemistry*-
dc.subject.MESHMale-
dc.subject.MESHMaterials Testing-
dc.subject.MESHNanocapsules/chemistry*-
dc.subject.MESHNanocapsules/ultrastructure-
dc.subject.MESHPolyglycolic Acid/chemistry*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHSurface Properties-
dc.subject.MESHTissue Adhesions/drug therapy*-
dc.subject.MESHTissue Adhesions/pathology-
dc.subject.MESHTreatment Outcome-
dc.titleEpigallocatechin-3-O-Gallate-Loaded Poly(lactic-co-glycolic acid) Fibrous Sheets as Anti-Adhesion Barriers-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Medical Engineering-
dc.contributor.googleauthorLee Jong Ho-
dc.contributor.googleauthorShin Yong Cheol-
dc.contributor.googleauthorYang Won Jun-
dc.contributor.googleauthorPark Jong-Chul-
dc.contributor.googleauthorHyon Suong-Hyu-
dc.contributor.googleauthorHan Dong-Wook-
dc.identifier.doiX-
dc.contributor.localIdA01662-
dc.relation.journalcodeJ01268-
dc.identifier.eissn1550-7041-
dc.identifier.pmid26295146-
dc.identifier.urlhttp://www.ingentaconnect.com/content/asp/jbn/2015/00000011/00000008/art00013-
dc.subject.keywordELECTROSPINNING-
dc.subject.keywordEPIGALLOCATECHIN-3-O-GALLATE-
dc.subject.keywordFIBROUS SHEET-
dc.subject.keywordPOLY(LACTIC-CO-GLYCOLIC ACID)-
dc.subject.keywordTISSUE-ADHESION BARRIER-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.affiliatedAuthorPark, Jong Chul-
dc.citation.volume11-
dc.citation.number8-
dc.citation.startPage1461-
dc.citation.endPage1471-
dc.identifier.bibliographicCitationJOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Vol.11(8) : 1461-1471, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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