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Altered resting-state functional connectivity in women with chronic fatigue syndrome

Authors
 Byung-Hoon Kim  ;  Kee Namkoong  ;  Jae-Jin Kim  ;  Seo jung Lee  ;  KangJoon Yoon  ;  Moonjong Choi  ;  Young-Chul Jung 
Citation
 PSYCHIATRY RESEARCH, Vol.234(3) : 292-297, 2015 
Journal Title
 PSYCHIATRY RESEARCH 
ISSN
 0165-1781 
Issue Date
2015
MeSH
Adult ; Brain/physiopathology ; Brain Mapping* ; Case-Control Studies ; Fatigue Syndrome, Chronic/pathology ; Fatigue Syndrome, Chronic/physiopathology* ; Female ; Gyrus Cinguli/physiopathology* ; Humans ; Magnetic Resonance Imaging/methods* ; Middle Aged ; Neural Pathways/physiopathology ; Rest/physiology*
Keywords
Chronic fatigue syndrome ; Default mode network ; Resting-state functional connectivity
Abstract
The biological underpinnings of the psychological factors characterizing chronic fatigue syndrome (CFS) have not been extensively studied. Our aim was to evaluate alterations of resting-state functional connectivity in CFS patients. Participants comprised 18 women with CFS and 18 age-matched female healthy controls who were recruited from the local community. Structural and functional magnetic resonance images were acquired during a 6-min passive-viewing block scan. Posterior cingulate cortex seeded resting-state functional connectivity was evaluated, and correlation analyses of connectivity strength were performed. Graph theory analysis of 90 nodes of the brain was conducted to compare the global and local efficiency of connectivity networks in CFS patients with that in healthy controls. The posterior cingulate cortex in CFS patients showed increased resting-state functional connectivity with the dorsal and rostral anterior cingulate cortex. Connectivity strength of the posterior cingulate cortex to the dorsal anterior cingulate cortex significantly correlated with the Chalder Fatigue Scale score, while the Beck Depression Inventory (BDI) score was controlled. Connectivity strength to the rostral anterior cingulate cortex significantly correlated with the Chalder Fatigue Scale score. Global efficiency of the posterior cingulate cortex was significantly lower in CFS patients, while local efficiency showed no difference from findings in healthy controls. The findings suggest that CFS patients show inefficient increments in resting-state functional connectivity that are linked to the psychological factors observed in the syndrome.
Full Text
http://www.sciencedirect.com/science/article/pii/S0925492715301359
DOI
10.1016/j.pscychresns.2015.10.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157206
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