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Pandemic influenza virus, pH1N1, induces asthmatic symptoms via activation of innate lymphoid cells

Authors
 D. H. Shim  ;  Y. A. Park  ;  M. J. Kim  ;  J. Y. Hong  ;  J. Y. Baek  ;  K. W. Kim  ;  Y.-h. Byun  ;  B.-L. Seong  ;  S. Ryu  ;  M. K. Song  ;  K.-J. Hong  ;  W.Na  ;  D. Song  ;  J. H. Park  ;  M. H. Sohn  ;  J. M. Lee 
Citation
 PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol.26(8) : 780-788, 2015 
Journal Title
 PEDIATRIC ALLERGY AND IMMUNOLOGY 
ISSN
 0905-6157 
Issue Date
2015
MeSH
Adolescent ; Animals ; Asthma/immunology ; Child ; Child, Preschool ; Female ; Humans ; Immunity, Innate ; Influenza A Virus, H1N1 Subtype/immunology* ; Influenza, Human/epidemiology ; Influenza, Human/immunology* ; Lymphocytes/immunology* ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Orthomyxoviridae Infections/immunology* ; Pandemics* ; Retrospective Studies
Keywords
airway hyper-responsiveness ; asthmatic symptoms ; infection ; influenza ; innate lymphoid cells
Abstract
BACKGROUND: The pandemic strain of the influenza A virus (pH1N1) in 2009 caused many complications in patients. In this study, we introduce asthmatic symptoms as a complication of pH1N1 infection in children, not having a relationship with asthma history. The aim of this study was to quantify asthmatic symptoms in pH1N1-infected children and elucidate the underlying mechanisms of airway hyper-responsiveness (AHR) induced in a murine model of pH1N1 infection. METHODS: As a retrospective study, pH1N1-infected children who were hospitalized with moderate to severe acute asthmatic symptoms were enrolled and administered a methacholine challenge test (MCT) at 3 months post-discharge. Additionally, the induction of AHR by pH1N1 infection was measured by MCT in wild-type and Rag1(-/-) mice. The effect of the innate immune response on the development of AHR following pH1N1 infection was investigated. RESULTS: More than 70% of the pH1N1-infected children without a pre-infection diagnosis of asthma had a negative response on the MCT. None of these children had recurrent wheezing or asthma during the 3 years following pH1N1 infection. The development of AHR in pH1N1-infected mice was associated with an elevation in IL-33 and innate lymphoid cells 2 (ILC2). CONCLUSIONS: This study demonstrates that pH1N1 infection directly induces transient asthmatic symptoms in patients regardless of their medical history. pH1N1 infection was shown to stimulate the rapid development of AHR and Th2-type cytokine secretion in mice via the activation of ILC2; it may be activated independently of adaptive immunity.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/pai.12462/abstract
DOI
10.1111/pai.12462
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0002-5634-9709
Park, Young A(박영아)
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
Baek, Ji Young(백지영)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Shim, Doo Hee(심두희) ORCID logo https://orcid.org/0000-0002-6696-7199
Lee, Jae Myun(이재면) ORCID logo https://orcid.org/0000-0002-5273-3113
Hong, Jung Yeon(홍정연) ORCID logo https://orcid.org/0000-0003-0406-9956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157137
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