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Longitudinal analysis of retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in ethambutol-induced optic neuropathy

 Jinu Han  ;  Min Kwang Byun  ;  Junwon Lee  ;  So Young Han  ;  Jong Bok Lee  ;  Sueng-Han Han 
 Graefes Archive for Clinical and Experimental Ophthalmology, Vol.253(12) : 2293-2299, 2015 
Journal Title
 Graefes Archive for Clinical and Experimental Ophthalmology 
Issue Date
Adult ; Aged ; Antitubercular Agents/adverse effects* ; Color Vision/physiology ; Ethambutol/adverse effects* ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Nerve Fibers/pathology* ; Optic Nerve Diseases/chemically induced* ; Optic Nerve Diseases/diagnosis* ; Prospective Studies ; Retinal Ganglion Cells/pathology* ; Tomography, Optical Coherence ; Tuberculosis, Pulmonary/drug therapy ; Visual Acuity/physiology ; Visual Field Tests
Ethambutol-induced optic neuropathy ; Ganglion cell–inner plexiform layer ; Mitochondrial optic neuropathy ; Retinal nerve fiber layer
PURPOSE: The aim of the study was to evaluate longitudinal analysis of peripapillary retinal nerve fiber layer (RNFL) and perifoveal ganglion cell-inner plexiform layer (GCIPL) thickness in patients being treated with ethambutol (EMB). METHODS: This prospective longitudinal cohort study enrolled 37 patients who were treated with EMB for pulmonary tuberculosis. Best-corrected visual acuity, color vision test, automated perimetry, fundus photography, and RNFL and GCIPL thickness were measured at baseline and at 4 and 6 months after the start of EMB treatment, using Cirrus optical coherence tomography. RESULTS: Among 37 patients, EMB-induced optic neuropathy occurred in one patient (2.7 %). In this patient, thickening of the RFNL and thinning of the GCIPL were noted at the onset of symptoms. After discontinuation of EMB, RNFL and GCIPL thickness progressively normalized. Changes in RNFL and GCIPL thickness were not statistically significant in the 36 patients who did not exhibit EMB-induced optic neuropathy-related symptoms during follow-up (all P values > 0.05). CONCLUSIONS: Thickening of the peripapillary RNFL and thinning of the perifoveal GCIPL is an effective quantitative and early marker for diagnosis of EMB-induced optic neuropathy.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
변민광(Byun, Min Kwang) ORCID logo https://orcid.org/0000-0003-1525-1745
이종복(Lee, Jong Bok)
이준원(Lee, Jun Won) ORCID logo https://orcid.org/0000-0003-0543-7132
한소영(Han, So Young)
한승한(Han, Seung Han) ORCID logo https://orcid.org/0000-0001-8972-4790
한진우(Han, Jinu) ORCID logo https://orcid.org/0000-0002-8607-6625
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