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An experimental approach to study the function of mitochondria in cardiomyopathy

Authors
 Youn Wook Chung  ;  Seok-Min Kang 
Citation
 BMB Reports, Vol.48(10) : 541-548, 2015 
Journal Title
 BMB Reports 
ISSN
 1976-6696 
Issue Date
2015
MeSH
Animals ; Cardiomyopathies/metabolism ; Cardiomyopathies/physiopathology* ; Cardiomyopathies/therapy ; Humans ; Mitochondria, Heart/genetics ; Mitochondria, Heart/metabolism ; Mitochondria, Heart/physiology*
Abstract
Cardiomyopathy is an inherited or acquired disease of the myocardium, which can result in severe ventricular dysfunction. Mitochondrial dysfunction is involved in the pathological process of cardiomyopathy. Many dysfunctions in cardiac mitochondria are consequences of mutations in nuclear or mitochondrial DNA followed by alterations in transcriptional regulation, mitochondrial protein function, and mitochondrial dynamics and energetics, presenting with associated multisystem mitochondrial disorders. To ensure correct diagnosis and optimal management of mitochondrial dysfunction in cardiomyopathy caused by multiple pathogenesis, multidisciplinary approaches are required, and to integrate between clinical and basic sciences, ideal translational models are needed. In this review, we will focus on experimental models to provide insights into basic mitochondrial physiology and detailed underlying mechanisms of cardiomyopathy and current mitochondria-targeted therapies for cardiomyopathy.
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DOI
10.5483/BMBRep.2015.48.10.153
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Chung, Youn Wook(정연욱) ORCID logo https://orcid.org/0000-0002-4382-1410
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157081
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