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[(18)F] FP-CIT PET study in parkinsonian patients with leukoaraiosis

Authors
 M.J. Lee  ;  S.L. Kim  ;  H.I. Kim  ;  Y.J. Oh  ;  S.H. Lee  ;  H.K. Kim  ;  C.S. Han  ;  C.H. Lyoo  ;  Y.H. Ryu  ;  M.S. Lee 
Citation
 Parkinsonism & Related Disorders, Vol.21(7) : 704-708, 2015 
Journal Title
 Parkinsonism & Related Disorders 
ISSN
 1353-8020 
Issue Date
2015
MeSH
Aged ; Aged, 80 and over ; Corpus Striatum/diagnostic imaging ; Female ; Fluorine Radioisotopes* ; Humans ; Leukoaraiosis/diagnostic imaging* ; Leukoaraiosis/epidemiology* ; Male ; Parkinsonian Disorders/diagnostic imaging* ; Parkinsonian Disorders/epidemiology* ; Positron-Emission Tomography*/methods ; Substantia Nigra/diagnostic imaging
Keywords
Leukoaraiosis ; Parkinsonism ; [(18)F] FP-CIT PET
Abstract
BACKGROUNDS: Leukoaraiosis may present with slowly progressive parkinsonism indistinguishable from primary degenerative parkinsonism. Both leukoaraiosis and degenerative parkinsonism are an age-related disorder. Thus, comorbidity is expected to be common in elderly patients with parkinsonism. However, no systematic study has been reported on the clinical features indicating concomitant nigrostriatal dopaminergic denervation (NDD) in parkinsonian patients with leukoaraiosis. METHODS: We performed [(18)F] FP-CIT positron emission tomography studies in 42 consecutive parkinsonian patients with diffuse leukoaraiosis, but no basal ganglia vascular lesions. RESULTS: Twenty (48%) of the 42 patients had coexisting NDD. Compared to parkinsonian patients with isolated leukoaraiosis, those with coexisting NDD more frequently had asymmetric onset. They had similar degree of parkinsonian motor deficits in the legs, but greater rigidity and resting tremor in the arms. Consequently, they had less prominent lower body parkinsonism. They more frequently showed favorable response to levodopa treatment. They had similar burden of regional and total leukoaraiosis. Among a variety of clinical variables and MRI findings, only asymmetric onset and more than 30% improvement in UPDRS motor score by levodopa treatment were valuable indicators of coexisting NDD. CONCLUSIONS: We would like to recommend dopaminergic functional imaging studies for all parkinsonian patients with leukoaraiosis. Further studies are needed to confirm sensitivity and specificity of asymmetric onset and good levodopa response for the prediction of coexisting NDD in a different group of parkinsonian patients with leukoaraiosis.
Full Text
http://www.sciencedirect.com/science/article/pii/S1353802015001558
DOI
10.1016/j.parkreldis.2015.04.007
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
Yonsei Authors
김샤롬(Kim, Sha Lom)
김한결(Kim, Han kyeol)
김혜인(Kim, Hye Ihn)
류철형(Lyoo, Chul Hyoung)
오여진(Oh, Yeo Jin)
유영훈(Ryu, Young Hoon)
이명식(Lee, Myung Sik)
이승하(Lee, Seung Ha)
한철수(Han, Cheol Soo)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157076
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