0 1036

Cited 6 times in

[(18)F] FP-CIT PET study in parkinsonian patients with leukoaraiosis

DC Field Value Language
dc.contributor.author김샤롬-
dc.contributor.author김한결-
dc.contributor.author김혜인-
dc.contributor.author류철형-
dc.contributor.author오여진-
dc.contributor.author유영훈-
dc.contributor.author이명식-
dc.contributor.author이승하-
dc.contributor.author한철수-
dc.date.accessioned2018-03-26T17:00:58Z-
dc.date.available2018-03-26T17:00:58Z-
dc.date.issued2015-
dc.identifier.issn1353-8020-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157076-
dc.description.abstractBACKGROUNDS: Leukoaraiosis may present with slowly progressive parkinsonism indistinguishable from primary degenerative parkinsonism. Both leukoaraiosis and degenerative parkinsonism are an age-related disorder. Thus, comorbidity is expected to be common in elderly patients with parkinsonism. However, no systematic study has been reported on the clinical features indicating concomitant nigrostriatal dopaminergic denervation (NDD) in parkinsonian patients with leukoaraiosis. METHODS: We performed [(18)F] FP-CIT positron emission tomography studies in 42 consecutive parkinsonian patients with diffuse leukoaraiosis, but no basal ganglia vascular lesions. RESULTS: Twenty (48%) of the 42 patients had coexisting NDD. Compared to parkinsonian patients with isolated leukoaraiosis, those with coexisting NDD more frequently had asymmetric onset. They had similar degree of parkinsonian motor deficits in the legs, but greater rigidity and resting tremor in the arms. Consequently, they had less prominent lower body parkinsonism. They more frequently showed favorable response to levodopa treatment. They had similar burden of regional and total leukoaraiosis. Among a variety of clinical variables and MRI findings, only asymmetric onset and more than 30% improvement in UPDRS motor score by levodopa treatment were valuable indicators of coexisting NDD. CONCLUSIONS: We would like to recommend dopaminergic functional imaging studies for all parkinsonian patients with leukoaraiosis. Further studies are needed to confirm sensitivity and specificity of asymmetric onset and good levodopa response for the prediction of coexisting NDD in a different group of parkinsonian patients with leukoaraiosis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science-
dc.relation.isPartOfPARKINSONISM & RELATED DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCorpus Striatum/diagnostic imaging-
dc.subject.MESHFemale-
dc.subject.MESHFluorine Radioisotopes*-
dc.subject.MESHHumans-
dc.subject.MESHLeukoaraiosis/diagnostic imaging*-
dc.subject.MESHLeukoaraiosis/epidemiology*-
dc.subject.MESHMale-
dc.subject.MESHParkinsonian Disorders/diagnostic imaging*-
dc.subject.MESHParkinsonian Disorders/epidemiology*-
dc.subject.MESHPositron-Emission Tomography*/methods-
dc.subject.MESHSubstantia Nigra/diagnostic imaging-
dc.title[(18)F] FP-CIT PET study in parkinsonian patients with leukoaraiosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorM.J. Lee-
dc.contributor.googleauthorS.L. Kim-
dc.contributor.googleauthorH.I. Kim-
dc.contributor.googleauthorY.J. Oh-
dc.contributor.googleauthorS.H. Lee-
dc.contributor.googleauthorH.K. Kim-
dc.contributor.googleauthorC.S. Han-
dc.contributor.googleauthorC.H. Lyoo-
dc.contributor.googleauthorY.H. Ryu-
dc.contributor.googleauthorM.S. Lee-
dc.identifier.doi10.1016/j.parkreldis.2015.04.007-
dc.contributor.localIdA00539-
dc.contributor.localIdA05235-
dc.contributor.localIdA04740-
dc.contributor.localIdA01333-
dc.contributor.localIdA04769-
dc.contributor.localIdA02485-
dc.contributor.localIdA02753-
dc.contributor.localIdA04628-
dc.contributor.localIdA04813-
dc.relation.journalcodeJ02468-
dc.identifier.eissn1873-5126-
dc.identifier.pmid25937616-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1353802015001558-
dc.subject.keywordLeukoaraiosis-
dc.subject.keywordParkinsonism-
dc.subject.keyword[(18)F] FP-CIT PET-
dc.contributor.alternativeNameKim, Sha Lom-
dc.contributor.alternativeNameKim, Han kyeol-
dc.contributor.alternativeNameKim, Hye Ihn-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.alternativeNameOh, Yeo Jin-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.alternativeNameLee, Myung Sik-
dc.contributor.alternativeNameLee, Seung Ha-
dc.contributor.alternativeNameHan, Cheol Soo-
dc.contributor.affiliatedAuthorKim, Sha Lom-
dc.contributor.affiliatedAuthorKim, Han kyeol-
dc.contributor.affiliatedAuthorKim, Hye Ihn-
dc.contributor.affiliatedAuthorLyoo, Chul Hyoung-
dc.contributor.affiliatedAuthorOh, Yeo Jin-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.contributor.affiliatedAuthorLee, Myung Sik-
dc.contributor.affiliatedAuthorLee, Seung Ha-
dc.contributor.affiliatedAuthorHan, Cheol Soo-
dc.citation.volume21-
dc.citation.number7-
dc.citation.startPage704-
dc.citation.endPage708-
dc.identifier.bibliographicCitationPARKINSONISM & RELATED DISORDERS, Vol.21(7) : 704-708, 2015-
dc.identifier.rimsid41640-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.