67 115

Cited 4 times in

The efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia

Authors
 Sang Bum Kim  ;  Jang Hoon Lee  ;  Juyoung Lee  ;  Seung Han Shin  ;  Ho Sun Eun  ;  Soon Min Lee  ;  Jin A Sohn  ;  Han Suk Kim  ;  Byung Min Choi  ;  Min Soo Park  ;  Kook In Park  ;  Ran Namgung  ;  Moon Sung Park 
Citation
 Korean Journal of Pediatrics, Vol.58(9) : 347-353, 2015 
Journal Title
 Korean Journal of Pediatrics 
ISSN
 1738-1061 
Issue Date
2015
Keywords
Broncopulmonary dysplasia ; Leukotriene antagonists ; Montelukast ; Pharmacokinetics ; Premature infant
Abstract
PURPOSE: The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD). METHODS: The Interventional study was designed as a multicenter, prospective, and randomized trial, with open labeled and parallel-experimental groups, 66 infants were enrolled and allocated to either the case group (n=30) or the control group (n=36) based on gestational age (GA). Infants in the case group were given Montelukast sodium (Singulair) based on their body weight (BW). Zero week was defined as the start time of the study. RESULTS: The incidence of moderate to severe BPD was not different between the groups (case group: 13 of 30 [43.3%] vs. control group: 19 of 36 [52.8%], P=0.912). Additionally, secondary outcomes such as ventilation index, mean airway pressure and resort to systemic steroids were not significantly different. There were no serious adverse drug reactions in either group, and furthermore the rate of occurrence of mild drug related-events were not significantly different (case group: 10 of 42 [23.8%] vs. control group: 6 of 48 (15.8%), P=0.414). CONCLUSION: Montelukast was not effective in reducing moderate or severe BPD. There were no significant adverse drug events associated with Montelukast treatment.
Files in This Item:
T201505104.pdf Download
DOI
10.3345/kjp.2015.58.9.347
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Namgung, Ran(남궁란) ORCID logo https://orcid.org/0000-0001-7182-9535
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Eun, Ho Seon(은호선) ORCID logo https://orcid.org/0000-0001-7212-0341
Lee, Soon Min(이순민) ORCID logo https://orcid.org/0000-0003-0174-1065
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157026
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse