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The efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia

DC Field Value Language
dc.contributor.author남궁란-
dc.contributor.author박국인-
dc.contributor.author박민수-
dc.contributor.author은호선-
dc.contributor.author이순민-
dc.date.accessioned2018-03-26T16:58:20Z-
dc.date.available2018-03-26T16:58:20Z-
dc.date.issued2015-
dc.identifier.issn1738-1061-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157026-
dc.description.abstractPURPOSE: The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD). METHODS: The Interventional study was designed as a multicenter, prospective, and randomized trial, with open labeled and parallel-experimental groups, 66 infants were enrolled and allocated to either the case group (n=30) or the control group (n=36) based on gestational age (GA). Infants in the case group were given Montelukast sodium (Singulair) based on their body weight (BW). Zero week was defined as the start time of the study. RESULTS: The incidence of moderate to severe BPD was not different between the groups (case group: 13 of 30 [43.3%] vs. control group: 19 of 36 [52.8%], P=0.912). Additionally, secondary outcomes such as ventilation index, mean airway pressure and resort to systemic steroids were not significantly different. There were no serious adverse drug reactions in either group, and furthermore the rate of occurrence of mild drug related-events were not significantly different (case group: 10 of 42 [23.8%] vs. control group: 6 of 48 (15.8%), P=0.414). CONCLUSION: Montelukast was not effective in reducing moderate or severe BPD. There were no significant adverse drug events associated with Montelukast treatment.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한소아과학회-
dc.relation.isPartOfKorean Journal of Pediatrics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorSang Bum Kim-
dc.contributor.googleauthorJang Hoon Lee-
dc.contributor.googleauthorJuyoung Lee-
dc.contributor.googleauthorSeung Han Shin-
dc.contributor.googleauthorHo Sun Eun-
dc.contributor.googleauthorSoon Min Lee-
dc.contributor.googleauthorJin A Sohn-
dc.contributor.googleauthorHan Suk Kim-
dc.contributor.googleauthorByung Min Choi-
dc.contributor.googleauthorMin Soo Park-
dc.contributor.googleauthorKook In Park-
dc.contributor.googleauthorRan Namgung-
dc.contributor.googleauthorMoon Sung Park-
dc.identifier.doi10.3345/kjp.2015.58.9.347-
dc.contributor.localIdA01241-
dc.contributor.localIdA01438-
dc.contributor.localIdA01468-
dc.contributor.localIdA02635-
dc.contributor.localIdA02905-
dc.relation.journalcodeJ02100-
dc.identifier.eissn2092-7258-
dc.identifier.pmid26512261-
dc.subject.keywordBroncopulmonary dysplasia-
dc.subject.keywordLeukotriene antagonists-
dc.subject.keywordMontelukast-
dc.subject.keywordPharmacokinetics-
dc.subject.keywordPremature infant-
dc.contributor.alternativeNameNamgung, Ran-
dc.contributor.alternativeNamePark, Kook In-
dc.contributor.alternativeNamePark, Min Soo-
dc.contributor.alternativeNameEun, Ho Seon-
dc.contributor.alternativeNameLee, Soon Min-
dc.contributor.affiliatedAuthorNamgung, Ran-
dc.contributor.affiliatedAuthorPark, Kook In-
dc.contributor.affiliatedAuthorPark, Min Soo-
dc.contributor.affiliatedAuthorEun, Ho Seon-
dc.contributor.affiliatedAuthorLee, Soon Min-
dc.citation.volume58-
dc.citation.number9-
dc.citation.startPage347-
dc.citation.endPage353-
dc.identifier.bibliographicCitationKorean Journal of Pediatrics, Vol.58(9) : 347-353, 2015-
dc.identifier.rimsid41335-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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