Cited 28 times in
Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila
DC Field | Value | Language |
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dc.contributor.author | 김철훈 | - |
dc.contributor.author | 문석준 | - |
dc.contributor.author | 박지나 | - |
dc.contributor.author | 서정택 | - |
dc.contributor.author | 이나영 | - |
dc.date.accessioned | 2018-03-26T16:58:01Z | - |
dc.date.available | 2018-03-26T16:58:01Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157017 | - |
dc.description.abstract | Cilia are highly specialized antennae-like cellular organelles. Inositol polyphosphate 5-phosphatase E (INPP5E) converts PI(4,5)P2 into PI4P and is required for proper ciliary function. Although Inpp5e mutations are associated with ciliopathies in humans and mice, the precise molecular role INPP5E plays in cilia remains unclear. Here, we report that Drosophila INPP5E (dINPP5E) regulates ciliary protein trafficking by controlling the phosphoinositide composition of ciliary membranes. Mutations in dInpp5e lead to hearing deficits due to the mislocalization of dTULP and mechanotransduction channels, Inactive and NOMPC, in chordotonal cilia. Both loss of dINPP5E and ectopic expression of the phosphatidylinositol-4-phosphate 5-kinase Skittles increase PI(4,5)P2 levels in the ciliary base. The fact that Skittles expression phenocopies the dInpp5e mutants confirms a central role for PI(4,5)P2 in the regulation of dTULP, Inactive, and NOMPC localization. These data suggest that the spatial localization and levels of PI(4,5)P2 in ciliary membranes are important regulators of ciliary trafficking and function. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Movement/physiology | - |
dc.subject.MESH | Cilia/metabolism* | - |
dc.subject.MESH | Drosophila/metabolism* | - |
dc.subject.MESH | Phosphatidylinositols/metabolism* | - |
dc.subject.MESH | Protein Transport | - |
dc.subject.MESH | Signal Transduction | - |
dc.title | Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pharmacology | - |
dc.contributor.googleauthor | Jina Park | - |
dc.contributor.googleauthor | Nayoung Lee | - |
dc.contributor.googleauthor | Adriana Kavoussi | - |
dc.contributor.googleauthor | Jeong Taeg Seo | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Seok Jun Moon | - |
dc.identifier.doi | 10.1016/j.celrep.2015.12.009 | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A01358 | - |
dc.contributor.localId | A01683 | - |
dc.contributor.localId | A01905 | - |
dc.contributor.localId | A05258 | - |
dc.relation.journalcode | J00488 | - |
dc.identifier.eissn | 2211-1247 | - |
dc.identifier.pmid | 26723017 | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.alternativeName | Moon, Seok Jun | - |
dc.contributor.alternativeName | Park, Ji Na | - |
dc.contributor.alternativeName | Seo, Jeong Taeg | - |
dc.contributor.alternativeName | Lee, Nayoung | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Moon, Seok Jun | - |
dc.contributor.affiliatedAuthor | Park, Ji Na | - |
dc.contributor.affiliatedAuthor | Seo, Jeong Taeg | - |
dc.contributor.affiliatedAuthor | Lee, Nayoung | - |
dc.citation.volume | 13 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2808 | - |
dc.citation.endPage | 2816 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, Vol.13(12) : 2808-2816, 2015 | - |
dc.identifier.rimsid | 41326 | - |
dc.type.rims | ART | - |
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