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Cited 12 times in

Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila

DC FieldValueLanguage
dc.contributor.author김철훈-
dc.contributor.author문석준-
dc.contributor.author박지나-
dc.contributor.author서정택-
dc.contributor.author이나영-
dc.date.accessioned2018-03-26T16:58:01Z-
dc.date.available2018-03-26T16:58:01Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157017-
dc.description.abstractCilia are highly specialized antennae-like cellular organelles. Inositol polyphosphate 5-phosphatase E (INPP5E) converts PI(4,5)P2 into PI4P and is required for proper ciliary function. Although Inpp5e mutations are associated with ciliopathies in humans and mice, the precise molecular role INPP5E plays in cilia remains unclear. Here, we report that Drosophila INPP5E (dINPP5E) regulates ciliary protein trafficking by controlling the phosphoinositide composition of ciliary membranes. Mutations in dInpp5e lead to hearing deficits due to the mislocalization of dTULP and mechanotransduction channels, Inactive and NOMPC, in chordotonal cilia. Both loss of dINPP5E and ectopic expression of the phosphatidylinositol-4-phosphate 5-kinase Skittles increase PI(4,5)P2 levels in the ciliary base. The fact that Skittles expression phenocopies the dInpp5e mutants confirms a central role for PI(4,5)P2 in the regulation of dTULP, Inactive, and NOMPC localization. These data suggest that the spatial localization and levels of PI(4,5)P2 in ciliary membranes are important regulators of ciliary trafficking and function.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherCell Press-
dc.relation.isPartOfCell Reports-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Movement/physiology-
dc.subject.MESHCilia/metabolism*-
dc.subject.MESHDrosophila/metabolism*-
dc.subject.MESHPhosphatidylinositols/metabolism*-
dc.subject.MESHProtein Transport-
dc.subject.MESHSignal Transduction-
dc.titleCiliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pharmacology-
dc.contributor.googleauthorJina Park-
dc.contributor.googleauthorNayoung Lee-
dc.contributor.googleauthorAdriana Kavoussi-
dc.contributor.googleauthorJeong Taeg Seo-
dc.contributor.googleauthorChul Hoon Kim-
dc.contributor.googleauthorSeok Jun Moon-
dc.identifier.doi10.1016/j.celrep.2015.12.009-
dc.contributor.localIdA01057-
dc.contributor.localIdA01358-
dc.contributor.localIdA01683-
dc.contributor.localIdA01905-
dc.contributor.localIdA05258-
dc.relation.journalcodeJ00488-
dc.identifier.eissn2211-1247-
dc.identifier.pmid26723017-
dc.contributor.alternativeNameKim, Chul Hoon-
dc.contributor.alternativeNameMoon, Seok Jun-
dc.contributor.alternativeNamePark, Ji Na-
dc.contributor.alternativeNameSeo, Jeong Taeg-
dc.contributor.alternativeNameLee, Nayoung-
dc.contributor.affiliatedAuthorKim, Chul Hoon-
dc.contributor.affiliatedAuthorMoon, Seok Jun-
dc.contributor.affiliatedAuthorPark, Ji Na-
dc.contributor.affiliatedAuthorSeo, Jeong Taeg-
dc.contributor.affiliatedAuthorLee, Nayoung-
dc.citation.volume13-
dc.citation.number12-
dc.citation.startPage2808-
dc.citation.endPage2816-
dc.identifier.bibliographicCitationCell Reports, Vol.13(12) : 2808-2816, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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