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Tear Cytokines as Biomarkers for Chronic Graft-versus-Host Disease

 Ji Won Jung  ;  Soo Jung Han  ;  Mi Kyung Song  ;  Tae-im Kim  ;  Eung Kweon Kim  ;  Yoo Hong Min  ;  June-Won Cheong  ;  Kyoung Yul Seo 
 Biology of Blood and Marrow Transplantation, Vol.21(12) : 2079-2085, 2015 
Journal Title
 Biology of Blood and Marrow Transplantation 
Issue Date
Adolescent ; Adult ; Aged ; Biomarkers/metabolism ; Chronic Disease ; Eye/immunology* ; Eye/secretion ; Female ; Graft vs Host Disease/diagnosis* ; Graft vs Host Disease/immunology ; Graft vs Host Disease/pathology ; Graft vs Host Disease/prevention & control ; Hematologic Neoplasms/immunology ; Hematologic Neoplasms/pathology ; Hematologic Neoplasms/therapy* ; Hematopoietic Stem Cell Transplantation* ; Humans ; Immunosuppressive Agents/therapeutic use ; Interferon-gamma/immunology ; Interferon-gamma/secretion ; Interleukin-10/immunology ; Interleukin-10/secretion ; Interleukin-17/immunology ; Interleukin-17/secretion ; Interleukin-2/immunology ; Interleukin-2/secretion ; Interleukin-6/immunology ; Interleukin-6/secretion ; Male ; Prospective Studies ; Severity of Illness Index ; Tears/chemistry* ; Transplantation, Homologous ; Tumor Necrosis Factor-alpha/immunology ; Tumor Necrosis Factor-alpha/secretion
Chronic ocular GVHD severity ; Graft-versus-host disease ; Interleukin (IL)-10 ; Interleukin (IL)-6 ; Tear cytokines ; Tumor necrosis factor (TNF)-α
We investigated the tear cytokine profiles in patients who underwent stem cell transplantation (SCT) and attempted to evaluate whether tear cytokines are associated with the presence of systemic chronic graft-versus-host disease (GVHD), regardless of ocular GVHD status. We also tested tear cytokines as biomarkers for chronic ocular GVHD severity. Forty-four patients who underwent SCT were enrolled and their diagnosis of chronic GVHD was confirmed. Ocular surface parameters and tear cytokine profiles were evaluated and the correlations between concentrations of cytokines and ocular surface parameters or several chronic ocular GVHD severity scales were evaluated. Tear interleukin (IL)-2, IL-10, IL-17α, interferon (IFN)-γ, IL-6, and tumor necrosis factor (TNF)-α were elevated in patients with chronic systemic GVHD compared with patients without chronic systemic GVHD. Receiver-operating characteristic curve analysis revealed that area under the curve (AUC) values for tear IL-10 (AUC = .795), IL-17α (AUC = .821), IL-6 (AUC = .912), and TNF-α (AUC = .910) were significantly correlated with the presence of chronic GVHD (all P < .001). Tear IL-10, IL-6, and TNF-α showed a stronger correlation with ocular surface parameters than other cytokines and these cytokines also correlated with several chronic ocular GVHD severity scales (all P < .05). Our data suggest the tear cytokines are useful biomarkers for the diagnosis of chronic GVHD after SCT and chronic ocular GVHD severity.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Seo, Kyuong Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Song, Mi Kyung(송미경)
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
Jung, Ji Won(정지원)
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