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상아질 접착에서의 Chlorhexidine의 효과

Other Titles
 Chlorhexidine and Dentin Adhesion 
 이난주  ;  조진형  ;  곽은정  ;  박원서  ;  정복영  ;  김기덕  ;  방난심 
 Journal of Korean Academy of Advanced General Dentistry, Vol.5(2) : 77-86, 2016 
Journal Title
 Journal of Korean Academy of Advanced General Dentistry 
Issue Date
This review examines the fundamental mechanism of dentin-resin bond degradation, considers the factors related with this event and furthermore, describes the more practical way to prevent the degradation followed by restoration failure. In spite of rapid development of dental adhesive, dentin-resin bond stability and durability are still major challenge to clinicians. Bacause dentin has unique environments, which are humid and moist, compared to enamel, it is difficult to acquire complete bond. Also presence of endogeneous matrix-metalloproteinases (MMPs) in dentin substrate plays a crucial role in the degradation. So, in order to prevent the degradation, complete infiltration of resin monomer to moist dentin substrate and inhibition of MMPs are essential in bonding process. There are multiple in vivo and in vitro reports showing that the durability and longevity of the dentin-resin bond interface is increased when nonspecific enzyme inhibitors, especially Chlorhexidine (CHX) are used. Among many synthetic inhibitors, chlorhexidine (CHX) is the most widely used MMPs-inhibitor because of its ‘substantivity’. Via its cationic-chelation mechanism, it inhibits MMPs (especially MMP-2, -9) effectively and consequently, reduces nanoleakage and increases bond stability. Also the use of CHX does not affect the immediate bond strength overall and gives no harm to mechanical properties of following adhesive resin. To sum up, the adoption of CHX is recommended as means of improving bond stability at this time.
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Eun Jung(곽은정)
Kim, Kee Deog(김기덕) ORCID logo https://orcid.org/0000-0003-3055-5130
Nam, Woong(남웅) ORCID logo https://orcid.org/0000-0003-0146-3624
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Pang, Nan Sim(방난심) ORCID logo https://orcid.org/0000-0003-4265-673X
Lee, Nan Ju(이난주)
Jung, Bok Yeong(정복영) ORCID logo https://orcid.org/0000-0002-8186-2109
Cho, Jin Hyung(조진형)
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