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Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduced body adiposity and Lp-PLA2 activity in overweight subjects

Authors
 Saem Jung  ;  Young Ju Lee  ;  Minkyung Kim  ;  Minjoo Kim  ;  Jung Hyun Kwak  ;  Ji-Won Lee  ;  Young-Tae Ahn  ;  Jae-Hun Sim  ;  Jong Ho Lee 
Citation
 Journal of Functional Foods, Vol.19(Part A) : 744-752, 2015 
Journal Title
 Journal of Functional Foods 
Issue Date
2015
Abstract
The effect of consumption of two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, on weight loss, body adiposity and lipoprotein-associated phospholipase A2 (Lp-PLA2) activities in overweight subjects was examined. After 12-week probiotic treatment, the probiotic group presented reductions in body weight (−0.65 ± 0.23 kg), body fat percentage (−0.57 ± 0.19%) and body fat mass (−616 ± 161 g) measured using DEXA, and L1 subcutaneous fat area (−2.68 ± 1.31 cm2) measured using CT, compared to baseline. The probiotic group exhibited greater reductions in oxidized low density lipoprotein (ox-LDL) (P < 0.001) and Lp-PLA2 (P < 0.001) and a greater increase in low density lipoprotein (LDL) particle size (P = 0.001) than the placebo. The change (△, difference from baseline) in total fat mass correlated with △ Lp-PLA2 (r = 0.480, P < 0.001), which correlated with △ ox-LDL (r = 0.537, P < 0.001). Probiotic-induced weight loss was associated with reductions in fat mass, which correlated with the changes in Lp-PLA2 activities (ClinicalTrials.gov: NCT02492698).
Full Text
http://www.sciencedirect.com/science/article/pii/S1756464615005034
DOI
10.1016/j.jff.2015.10.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
이지원(Lee, Ji Won) ORCID logo https://orcid.org/0000-0002-2666-4249
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/155659
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