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Ultrasound texture analysis: Association with lymph node metastasis of papillary thyroid microcarcinoma

Authors
 Soo-Yeon Kim  ;  Eunjung Lee  ;  Se Jin Nam  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Jung Hyun Yoon  ;  Kyung Hwa Han  ;  Jin Young Kwak 
Citation
 PLoS One, Vol.12(4) : e0176103, 2017 
Journal Title
 PLoS One 
Issue Date
2017
MeSH
Adolescent ; Adult ; Aged ; Carcinoma, Papillary/diagnostic imaging ; Carcinoma, Papillary/pathology* ; Carcinoma, Papillary/surgery ; Female ; Humans ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology* ; Lymphatic Metastasis/diagnostic imaging ; Lymphatic Metastasis/pathology* ; Male ; Middle Aged ; Retrospective Studies ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/pathology* ; Thyroid Gland/surgery ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology* ; Thyroid Neoplasms/surgery ; Thyroidectomy ; Ultrasonography ; Young Adult
Abstract
This retrospective study aimed to evaluate whether ultrasound texture analysis is useful to predict lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC). This study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. Between May and July 2013, 361 patients (mean age, 43.8 ± 11.3 years; range, 16-72 years) who underwent staging ultrasound (US) and subsequent thyroidectomy for conventional PTMC ≤ 10 mm between May and July 2013 were included. Each PTMC was manually segmented and its histogram parameters (Mean, Standard deviation, Skewness, Kurtosis, and Entropy) were extracted with Matlab software. The mean values of histogram parameters and clinical and US features were compared according to lymph node metastasis using the independent t-test and Chi-square test. Multivariate logistic regression analysis was performed to identify the independent factors associated with lymph node metastasis. Tumors with lymph node metastasis (n = 117) had significantly higher entropy compared to those without lymph node metastasis (n = 244) (mean±standard deviation, 6.268±0.407 vs. 6.171±.0.405; P = .035). No additional histogram parameters showed differences in mean values according to lymph node metastasis. Entropy was not independently associated with lymph node metastasis on multivariate logistic regression analysis (Odds ratio, 0.977 [95% confidence interval (CI), 0.482-1.980]; P = .949). Younger age (Odds ratio, 0.962 [95% CI, 0.940-0.984]; P = .001) and lymph node metastasis on US (Odds ratio, 7.325 [95% CI, 3.573-15.020]; P < .001) were independently associated with lymph node metastasis. Texture analysis was not useful in predicting lymph node metastasis in patients with PTMC.
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DOI
10.1371/journal.pone.0176103
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
곽진영(Kwak, Jin Young) ORCID logo https://orcid.org/0000-0002-6212-1495
김은경(Kim, Eun-Kyung) ORCID logo https://orcid.org/0000-0002-3368-5013
남세진(Nam, Se Jin)
문희정(Moon, Hee Jung) ORCID logo https://orcid.org/0000-0002-5643-5885
윤정현(Yoon, Jung Hyun) ORCID logo https://orcid.org/0000-0002-2100-3513
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154615
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